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Trabectedin

A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.

297+ PubMed studies analyzed · 16 RCTs · Evidence Score: 51.6

Research Domains

Trabectedin has been studied across 11 research domains including 🔬 Oncology, 🧬 Hormones, 🫁 Liver & Detox, 🔬 Inflammation, 🛡️ Immunity. The primary research focus is 🔬 Oncology with 64% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Trabectedin, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Teniposide
6 shared targets
Clofarabine
13 shared targets
Tomatine
6 shared targets
Thapsigargin
8 shared targets
Epirubicin
7 shared targets
Thioinosine
8 shared targets
Polidocanol
10 shared targets
Desonide
6 shared targets
Itraconazole
8 shared targets
Proscillaridin
8 shared targets
Loading evidence profile...

This evidence profile for Trabectedin is generated deterministically from 297 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.