Erythrocytes take up carbon dioxide and release oxygen

Q: What compounds affect the Erythrocytes take up carbon dioxide and release oxygen pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Erythrocytes take up carbon dioxide and release oxygen pathway (Reactome ID: R-HSA-1237044). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-12370446 genes71 compounds

The Erythrocytes take up carbon dioxide and release oxygen pathway (Reactome ID: R-HSA-1237044) involves 6 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CA1 CA2 CA4 HBA1 HBA2 HBB

Compounds Affecting Erythrocytes take up carbon dioxide and release oxygen

#	Compound	Targets Hit	Studies
1	Zonisamide	—	297
2	benzolamide	—	188
3	Histidine	—	158
4	Chlorthalidone	—	299
5	Furosemide	—	298
6	Indapamide	—	299
7	Sulfanilamide	—	300
8	chrysin	—	300
9	Quercetin	—	300
10	Bortezomib	—	300
11	Bumetanide	—	299
12	stx64	—	2
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Catechin	—	51
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Resveratrol	—	298
17	Spermidine	—	241
18	Catechin	—	300
19	Famotidine	—	296
20	Lacosamide	—	297
21	Phenol	—	297
22	4-Hydroxybenzoate-3-Monooxygenase	—	300
23	diallyl trisulfide	—	246
24	Sulpiride	—	299
25	Histamine	—	300
26	Tyrosine	—	43
27	Tyrosine	—	300
28	Hydrogen Sulfide	—	299
29	Hydrogen Sulfide	—	300
30	Sulfides Chemical groups containing	—	300
31	Salicylic Acid	—	298
32	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
33	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
34	caffeic acid	—	300
35	d609	—	49
36	Vanillic Acid	—	300
37	thiamine	—	299
38	Mafenide	—	169
39	Celecoxib	—	295
40	Metolazone	—	166
41	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
42	Levodopa	—	297
43	Sodium Azide	—	300
44	Hydrogen Cyanide Hydrogen cyanide (HCN);	—	298
45	Epinephrine	—	299
46	Carnosine	—	223
47	Cyanides Inorganic salts of HYDROGEN CYANIDE containing	—	300
48	Aspartic Acid	—	300
49	Glutamic Acid	—	297
50	Glutamic Acid	—	300

About the Erythrocytes take up carbon dioxide and release oxygen Pathway

The Erythrocytes take up carbon dioxide and release oxygen pathway is catalogued in Reactome (ID: R-HSA-1237044) and involves 6 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CA1, CA2, CA4, HBA1, HBA2.