What compounds target CA4?

BiohacksAI has identified 35 compounds that interact with CA4 (carbonic anhydrase 4). Top compounds include: Indapamide, Phenol, Zonisamide, Celecoxib, Chlorthalidone. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CA4 (carbonic anhydrase 4)?

CA4 is carbonic anhydrase 4. It is a molecular target for 35 compounds documented in PubMed bioassay data. UniProt ID: P22748. NCBI Gene ID: 762.

CA4

MOLECULAR TARGET

carbonic anhydrase 4

UniProt: P22748 NCBI Gene: 76235 compounds

CA4 (carbonic anhydrase 4) is targeted by 35 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CA4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Indapamide	1.95	6
2	Phenol	1.95	6
3	Zonisamide	1.95	6
4	Celecoxib	1.79	5
5	Chlorthalidone	1.79	5
6	Sulfanilamide	1.61	4
7	Histidine	1.39	3
8	Furosemide	1.39	3
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
10	Bumetanide	1.10	2
11	Mafenide	1.10	2
12	Metolazone	1.10	2
13	stx64	1.10	2
14	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
15	Catechin	0.69	1
16	chrysin	0.69	1
17	Pueraria	0.69	1
18	Kaempferols	0.69	1
19	Quercetin	0.69	1
20	Resveratrol	0.69	1
21	Spermidine	0.69	1
22	benzolamide	0.69	1
23	Bortezomib	0.69	1
24	Catechin	0.69	1
25	Famotidine	0.69	1
26	Hesperidin	0.69	1
27	Histamine	0.69	1
28	Secologanin Tryptamine Alkaloids Compounds formed by condensation of secologanin with tryptamine resulting in	0.69	1
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	0.69	1
30	Lacosamide	0.69	1
31	4-Hydroxybenzoate-3-Monooxygenase	0.69	1
32	Sodium Citrate Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in	0.69	1
33	Spermine	0.69	1
34	alphitonin [Supplementary Concept] from	0.69	1
35	tiliroside	0.69	1

About CA4 as a Drug Target

CA4 (carbonic anhydrase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 35 compounds with documented CA4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CA4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.