Question 1

What compounds affect the Transcription of E2F targets under negative control by DREAM complex pathway?

Accepted Answer

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcription of E2F targets under negative control by DREAM complex pathway (Reactome ID: R-HSA-1362277). These compounds target 5 genes within this pathway.

Question 2

What genes are in the Transcription of E2F targets under negative control by DREAM complex pathway?

Accepted Answer

The Transcription of E2F targets under negative control by DREAM complex pathway involves 5 genes. Key genes include: CDC25A, HDAC1, MYC, PCNA, TOP2A.

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Genistein	—	300
4	Quercetin	—	300
5	Ethidium	—	300
6	Teniposide	—	299
7	Topotecan	—	300
8	Ciprofloxacin	—	1,000
9	fisetin	—	78
10	Aclarubicin	—	300
11	Dexrazoxane	—	298
12	Digitoxin	—	300
13	Epirubicin	—	300
14	Idarubicin	—	299
15	Vorinostat	—	299
16	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
17	scriptaid	—	53
18	Valproic Acid	—	296
19	pictilisib	—	25
20	Butyric Acid	—	300
21	Ursolic Acid	—	300
22	Celecoxib	—	295
23	Bortezomib	—	300
24	Camptothecin	—	300
25	plumbagin [Supplementary Concept]	—	300
26	Vitamin K 3	—	300
27	Danazol	—	298
28	Methysergide	—	300
29	Oleanolic Acid	—	300
30	Triiodothyronine	—	300

BiohacksAI

Transcription of E2F targets under negative control by DREAM complex

Genes in this Pathway

Compounds Affecting Transcription of E2F targets under negative control by DREAM complex

About the Transcription of E2F targets under negative control by DREAM complex Pathway