A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Teniposide has been studied across 14 research domains including 🔬 Oncology, 😴 Sleep, 🫁 Liver & Detox, ⚡ Energy & Fatigue, 🧠 Focus & Attention. The primary research focus is 🔬 Oncology with 57% of studies addressing this area.
The following compounds share molecular targets with Teniposide, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.
This evidence profile for Teniposide is generated deterministically from 299 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.