What compounds affect the O2/CO2 exchange in erythrocytes pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the O2/CO2 exchange in erythrocytes pathway (Reactome ID: R-HSA-1480926). These compounds target 6 genes within this pathway.

What genes are in the O2/CO2 exchange in erythrocytes pathway?

The O2/CO2 exchange in erythrocytes pathway involves 6 genes. Key genes include: CA1, CA2, CA4, HBA1, HBA2, HBB.

O2/CO2 exchange in erythrocytes

REACTOME PATHWAY

Reactome: R-HSA-14809266 genes71 compounds

The O2/CO2 exchange in erythrocytes pathway (Reactome ID: R-HSA-1480926) involves 6 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CA1 CA2 CA4 HBA1 HBA2 HBB

Compounds Affecting O2/CO2 exchange in erythrocytes

#	Compound	Targets Hit	Studies
1	Zonisamide	—	297
2	benzolamide	—	188
3	Histidine	—	158
4	Chlorthalidone	—	299
5	Furosemide	—	298
6	Indapamide	—	299
7	Sulfanilamide	—	300
8	chrysin	—	300
9	Quercetin	—	300
10	Bortezomib	—	300
11	Bumetanide	—	299
12	stx64	—	2
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Catechin	—	51
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Resveratrol	—	298
17	Spermidine	—	241
18	Catechin	—	300
19	Famotidine	—	296
20	Lacosamide	—	297
21	Phenol	—	297
22	4-Hydroxybenzoate-3-Monooxygenase	—	300
23	diallyl trisulfide	—	246
24	Sulpiride	—	299
25	Histamine	—	300
26	Tyrosine	—	43
27	Tyrosine	—	300
28	Hydrogen Sulfide	—	299
29	Hydrogen Sulfide	—	300
30	Sulfides Chemical groups containing	—	300
31	Salicylic Acid	—	298
32	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
33	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
34	caffeic acid	—	300
35	d609	—	49
36	Vanillic Acid	—	300
37	thiamine	—	299
38	Mafenide	—	169
39	Celecoxib	—	295
40	Metolazone	—	166
41	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
42	Levodopa	—	297
43	Sodium Azide	—	300
44	Hydrogen Cyanide Hydrogen cyanide (HCN);	—	298
45	Epinephrine	—	299
46	Carnosine	—	223
47	Cyanides Inorganic salts of HYDROGEN CYANIDE containing	—	300
48	Aspartic Acid	—	300
49	Glutamic Acid	—	297
50	Glutamic Acid	—	300

About the O2/CO2 exchange in erythrocytes Pathway

The O2/CO2 exchange in erythrocytes pathway is catalogued in Reactome (ID: R-HSA-1480926) and involves 6 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CA1, CA2, CA4, HBA1, HBA2.