What compounds affect the Meiosis pathway?

63 compounds in the BiohacksAI corpus have documented interactions with genes in the Meiosis pathway (Reactome ID: R-HSA-1500620). These compounds target 8 genes within this pathway.

What genes are in the Meiosis pathway?

The Meiosis pathway involves 8 genes. Key genes include: ATM, BLM, BRCA1, CDK2, CDK4, LMNA, RAD51, RBBP8.

Meiosis

REACTOME PATHWAY

Reactome: R-HSA-15006208 genes63 compounds

The Meiosis pathway (Reactome ID: R-HSA-1500620) involves 8 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BLM BRCA1 CDK2 CDK4 LMNA RAD51 RBBP8

Compounds Affecting Meiosis

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	Methylene Blue	—	200
3	streptonigrin	—	299
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Resveratrol	—	298
6	Methotrexate	—	289
7	Astemizole Antihistamine drug now withdrawn from	—	280
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Calcimycin	—	216
11	calycosin	—	300
12	Chlorhexidine	—	299
13	Ciclopirox	—	88
14	Colchicine	—	300
15	colchine	—	2
16	cycloheximide	—	300
17	Cytarabine	—	297
18	Demecolcine	—	246
19	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
20	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
21	dihydrorotenone	—	13
22	Fluspirilene	—	74
23	gedunin	—	54
24	Hexachlorophene	—	300
25	lidoflazine	—	278
26	Melphalan	—	300
27	Niclosamide	—	299
28	Nocodazole Nocodazole is	—	215
29	paxilline	—	42
30	Podophyllotoxin	—	14
31	rafoxanide	—	172
32	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
33	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
34	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
35	Trifluridine	—	295
36	Tubercidin	—	300
37	vinblastine sulfate	—	81
38	Daunorubicin	—	298
39	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
40	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
41	Quercetin	—	300
42	Estramustine	—	300
43	Idarubicin	—	299
44	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
45	DEAD-box RNA Helicases	—	169
46	Thioctic Acid	—	298
47	Rosmarinic Acid	—	300
48	Dihydroxyphenylalanine	—	300
49	Levodopa	—	297
50	Vitamin K 3	—	300

About the Meiosis Pathway

The Meiosis pathway is catalogued in Reactome (ID: R-HSA-1500620) and involves 8 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BLM, BRCA1, CDK2, CDK4.