What compounds affect the Telomere Maintenance pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the Telomere Maintenance pathway (Reactome ID: R-HSA-157579). These compounds target 8 genes within this pathway.

What genes are in the Telomere Maintenance pathway?

The Telomere Maintenance pathway involves 8 genes. Key genes include: BLM, CCNA1, CDK2, DNA2, FEN1, PCNA, TERT, WRN.

Telomere Maintenance

REACTOME PATHWAY

Reactome: R-HSA-1575798 genes43 compounds

The Telomere Maintenance pathway (Reactome ID: R-HSA-157579) involves 8 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BLM CCNA1 CDK2 DNA2 FEN1 PCNA TERT WRN

Compounds Affecting Telomere Maintenance

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Aurintricarboxylic Acid	—	184
3	Ethidium	—	300
4	Levodopa	—	297
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Quercetin	—	300
7	Norepinephrine Precursor of epinephrine that is secreted by	—	298
8	Idarubicin	—	299
9	Methyldopa	—	297
10	Methylene Blue	—	200
11	Oxytetracycline	—	300
12	streptonigrin	—	299
13	alsterpaullone	—	12
14	kenpaullone	—	8
15	sp600125	—	117
16	Dequalinium	—	136
17	Diiodotyrosine	—	300
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Epinephrine	—	299
20	piceatannol	—	300
21	Doxycycline	—	999
22	Carmine Coloring matter from	—	300
23	Cisplatin	—	300
24	Demeclocycline	—	297
25	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
26	Daunorubicin	—	298
27	Estramustine	—	300
28	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
29	DEAD-box RNA Helicases	—	169
30	Thioctic Acid	—	298
31	Rosmarinic Acid	—	300
32	Dihydroxyphenylalanine	—	300
33	Vitamin K 3	—	300
34	Thioctic Acid	—	300
35	alpha-Linolenic Acid	—	300
36	Masoprocol	—	300
37	Methylergonovine	—	14
38	egcg	—	300
39	Oleic Acid	—	112
40	celastrol	—	300
41	Oleanolic Acid	—	300
42	Triiodothyronine	—	300
43	Uridine Triphosphate Uridine 5'-(tetrahydrogen triphosphate).	—	300

About the Telomere Maintenance Pathway

The Telomere Maintenance pathway is catalogued in Reactome (ID: R-HSA-157579) and involves 8 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BLM, CCNA1, CDK2, DNA2, FEN1.