What compounds affect the Frs2-mediated activation pathway?

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Frs2-mediated activation pathway (Reactome ID: R-HSA-170968). These compounds target 7 genes within this pathway.

What genes are in the Frs2-mediated activation pathway?

The Frs2-mediated activation pathway involves 7 genes. Key genes include: BRAF, MAP2K1, MAP2K2, MAPK1, MAPK3, NTRK1, YWHAB.

Frs2-mediated activation

REACTOME PATHWAY

Reactome: R-HSA-1709687 genes30 compounds

The Frs2-mediated activation pathway (Reactome ID: R-HSA-170968) involves 7 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF MAP2K1 MAP2K2 MAPK1 MAPK3 NTRK1 YWHAB

Compounds Affecting Frs2-mediated activation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	pd98059	—	7
3	trametinib	—	296
4	Dasatinib	—	299
5	Axitinib	—	298
6	Vemurafenib	—	298
7	plumbagin [Supplementary Concept]	—	300
8	alsterpaullone	—	12
9	kenpaullone	—	8
10	sp600125	—	117
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	withaferin	—	300
13	Quercetin	—	300
14	tyrphostin ag 1478	—	4
15	Clotrimazole	—	296
16	fisetin	—	78
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	Crizotinib	—	298
30	pictilisib	—	25

About the Frs2-mediated activation Pathway

The Frs2-mediated activation pathway is catalogued in Reactome (ID: R-HSA-170968) and involves 7 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, MAP2K1, MAP2K2, MAPK1, MAPK3.