Question 1

What compounds affect the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway?

Accepted Answer

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway (Reactome ID: R-HSA-176814). These compounds target 37 genes within this pathway.

Question 2

What genes are in the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway?

Accepted Answer

The Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway involves 37 genes. Key genes include: ADRM1, CCNA1, CCNB1, CDK1, NEK2, PLK1, PSMA1, PSMA2, PSMA3, PSMA4.

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	kenpaullone	—	8
5	alsterpaullone	—	12
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	chrysin	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	sp600125	—	117
10	indirubin	—	300
11	fisetin	—	78
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Disulfiram	—	297
14	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
15	Clofibrate	—	299
16	Fenofibrate	—	297
17	Sertraline	—	1,000
18	Cinnarizine	—	299
19	Clotrimazole	—	296
20	Rotenone	—	300
21	Sorafenib	—	300
22	ly294002	—	11
23	Wortmannin	—	300
24	Oleic Acid	—	112
25	Simvastatin	—	1,000
26	cefaclor	—	299
27	Hexachlorophene	—	300
28	Lithocholic Acid	—	300
29	Nisoldipine	—	297
30	Oxyphenbutazone	—	300
31	Oxytetracycline	—	300
32	4-Hydroxybenzoate-3-Monooxygenase	—	300
33	egcg	—	300
34	Genistein	—	300
35	Vemurafenib	—	298
36	Pioglitazone	—	297
37	Harmaline	—	300

BiohacksAI

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

Genes in this Pathway

Compounds Affecting Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

About the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Pathway