What genes are in the Norepinephrine Neurotransmitter Release Cycle pathway?

The Norepinephrine Neurotransmitter Release Cycle pathway involves 2 genes. Key genes include: MAOA, SLC22A1.

Norepinephrine Neurotransmitter Release Cycle

Q: What compounds affect the Norepinephrine Neurotransmitter Release Cycle pathway?

50 compounds in the BiohacksAI corpus have documented interactions with genes in the Norepinephrine Neurotransmitter Release Cycle pathway (Reactome ID: R-HSA-181430). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1814302 genes50 compounds

The Norepinephrine Neurotransmitter Release Cycle pathway (Reactome ID: R-HSA-181430) involves 2 genes and is affected by 50 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAOA SLC22A1

Compounds Affecting Norepinephrine Neurotransmitter Release Cycle

#	Compound	Targets Hit	Studies
1	Guanabenz	—	298
2	Iproniazid	—	300
3	Moclobemide	—	299
4	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Quercetin	—	300
7	Phenelzine	—	297
8	Genistein	—	300
9	Idazoxan	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Harmaline	—	300
12	hispidol	—	13
13	Linezolid	—	298
14	Vitamin K 3	—	300
15	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	—	300
16	chrysin	—	300
17	Methylene Blue	—	200
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	plumbagin [Supplementary Concept]	—	300
20	Sirolimus	—	300
21	Rutin	—	300
22	Aripiprazole	—	298
23	auraptene	—	148
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
25	Famotidine	—	296
26	Fentanyl	—	300
27	Guanfacine	—	294
28	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
29	Lynestrenol	—	299
30	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
31	pentamidine	—	299
32	Rilmenidine Oxazole derivative that acts as	—	300
33	Sorafenib	—	300
34	Clonidine	—	299
35	Procainamide	—	297
36	Quinidine	—	298
37	Cimetidine	—	299
38	ethopropazine	—	17
39	Phenformin	—	300
40	Progesterone	—	299
41	Carvedilol	—	296
42	Chlorhexidine	—	299
43	Corticosterone	—	300
44	Dextrorphan Dextro form of levorphanol. It acts as	—	300
45	Dinoprost	—	252
46	Dinoprostone	—	296
47	Ipratropium	—	297
48	Levorphanol	—	297
49	Pindolol	—	299
50	Pramipexole	—	297

About the Norepinephrine Neurotransmitter Release Cycle Pathway

The Norepinephrine Neurotransmitter Release Cycle pathway is catalogued in Reactome (ID: R-HSA-181430) and involves 2 genes. In the BiohacksAI corpus, 50 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAOA, SLC22A1.