Downstream signal transduction
REACTOME PATHWAYThe Downstream signal transduction pathway (Reactome ID: R-HSA-186763) involves 10 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Downstream signal transduction
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Dasatinib | — | 299 |
| 3 | pictilisib | — | 25 |
| 4 | ly294002 | — | 11 |
| 5 | Sirolimus | — | 300 |
| 6 | Resveratrol | — | 298 |
| 7 | Quercetin | — | 300 |
| 8 | Niclosamide | — | 299 |
| 9 | Wortmannin | — | 300 |
| 10 | alpelisib | — | 227 |
| 11 | tyrphostin ag 1295 | — | 1 |
| 12 | tyrphostin ag 1478 | — | 4 |
| 13 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 14 | Afatinib | — | 297 |
| 15 | alsterpaullone | — | 12 |
| 16 | Crizotinib | — | 298 |
| 17 | kenpaullone | — | 8 |
| 18 | monorden | — | 8 |
| 19 | torin 1 | — | 10 |
| 20 | Budesonide | — | 1,000 |
| 21 | Methylene Blue | — | 200 |
| 22 | egcg | — | 300 |
| 23 | Flurandrenolone | — | 65 |
| 24 | Hexachlorophene | — | 300 |
| 25 | streptonigrin | — | 299 |
| 26 | Avapritinib | — | 246 |
| 27 | Axitinib | — | 298 |
| 28 | Fingolimod Hydrochloride | — | 56 |
| 29 | Celecoxib | — | 295 |
| 30 | Dactinomycin | — | 297 |
About the Downstream signal transduction Pathway
The Downstream signal transduction pathway is catalogued in Reactome (ID: R-HSA-186763) and involves 10 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, PDGFRA, PDGFRB, PIK3CB, PIK3R1.