What compounds affect the Signaling by PDGF pathway?

33 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by PDGF pathway (Reactome ID: R-HSA-186797). These compounds target 12 genes within this pathway.

What genes are in the Signaling by PDGF pathway?

The Signaling by PDGF pathway involves 12 genes. Key genes include: FURIN, GRB2, PDGFRA, PDGFRB, PIK3CB, PIK3R1, PIK3R2, PLAT, SRC, STAT1.

Signaling by PDGF

REACTOME PATHWAY

Reactome: R-HSA-18679712 genes33 compounds

The Signaling by PDGF pathway (Reactome ID: R-HSA-186797) involves 12 genes and is affected by 33 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FURIN GRB2 PDGFRA PDGFRB PIK3CB PIK3R1 PIK3R2 PLAT SRC STAT1 STAT3 STAT5A

Compounds Affecting Signaling by PDGF

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	pictilisib	—	25
4	ly294002	—	11
5	Sirolimus	—	300
6	Resveratrol	—	298
7	Quercetin	—	300
8	Niclosamide	—	299
9	Wortmannin	—	300
10	alpelisib	—	227
11	tyrphostin ag 1295	—	1
12	tyrphostin ag 1478	—	4
13	Adenosine Monophosphate Adenine nucleotide containing	—	300
14	Afatinib	—	297
15	alsterpaullone	—	12
16	Crizotinib	—	298
17	kenpaullone	—	8
18	monorden	—	8
19	torin 1	—	10
20	Budesonide	—	1,000
21	Methylene Blue	—	200
22	egcg	—	300
23	Flurandrenolone	—	65
24	Hexachlorophene	—	300
25	streptonigrin	—	299
26	Avapritinib	—	246
27	Axitinib	—	298
28	Fingolimod Hydrochloride	—	56
29	Celecoxib	—	295
30	Diminazene	—	300
31	silver sulfadiazine	—	299
32	Bortezomib	—	300
33	Dactinomycin	—	297

About the Signaling by PDGF Pathway

The Signaling by PDGF pathway is catalogued in Reactome (ID: R-HSA-186797) and involves 12 genes. In the BiohacksAI corpus, 33 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FURIN, GRB2, PDGFRA, PDGFRB, PIK3CB.