What compounds affect the trans-Golgi Network Vesicle Budding pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the trans-Golgi Network Vesicle Budding pathway (Reactome ID: R-HSA-199992). These compounds target 5 genes within this pathway.

What genes are in the trans-Golgi Network Vesicle Budding pathway?

The trans-Golgi Network Vesicle Budding pathway involves 5 genes. Key genes include: APP, ARRB1, GAK, HSPA8, PIK3C2A.

trans-Golgi Network Vesicle Budding

REACTOME PATHWAY

Reactome: R-HSA-1999925 genes40 compounds

The trans-Golgi Network Vesicle Budding pathway (Reactome ID: R-HSA-199992) involves 5 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP ARRB1 GAK HSPA8 PIK3C2A

Compounds Affecting trans-Golgi Network Vesicle Budding

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	Resveratrol	—	298
3	Quercetin	—	300
4	egcg	—	300
5	Hesperidin	—	300
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	Kaempferols	—	300
8	Methylene Blue	—	200
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	caffeic acid	—	300
13	Vitamin	—	295
14	2-Methoxyestradiol	—	300
15	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
16	Cladribine	—	297
17	Digitoxin	—	300
18	Digoxin	—	299
19	Disulfiram	—	297
20	Edetic Acid	—	24
21	Catechin	—	300
22	Vanillic Acid	—	300
23	Ouabain	—	300
24	Podophyllotoxin	—	14
25	Quinic Acid	—	218
26	Retinaldehyde	—	300
27	streptonigrin	—	299
28	Trifluridine	—	295
29	Afatinib	—	297
30	alpelisib	—	227
31	Axitinib	—	298
32	Dasatinib	—	299
33	sp600125	—	117
34	aniracetam	—	110
35	Nadolol	—	297
36	Nicardipine	—	94
37	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
38	Hexachlorophene	—	300
39	Ergosterol	—	300
40	torin 1	—	10

About the trans-Golgi Network Vesicle Budding Pathway

The trans-Golgi Network Vesicle Budding pathway is catalogued in Reactome (ID: R-HSA-199992) and involves 5 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, ARRB1, GAK, HSPA8, PIK3C2A.