What compounds affect the Carnitine shuttle pathway?

96 compounds in the BiohacksAI corpus have documented interactions with genes in the Carnitine shuttle pathway (Reactome ID: R-HSA-200425). These compounds target 7 genes within this pathway.

What genes are in the Carnitine shuttle pathway?

The Carnitine shuttle pathway involves 7 genes. Key genes include: CPT2, PPARD, PRKAA2, PRKAB2, PRKAG2, RXRA, SLC22A5.

Carnitine shuttle

REACTOME PATHWAY

Reactome: R-HSA-2004257 genes96 compounds

The Carnitine shuttle pathway (Reactome ID: R-HSA-200425) involves 7 genes and is affected by 96 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CPT2 PPARD PRKAA2 PRKAB2 PRKAG2 RXRA SLC22A5

Compounds Affecting Carnitine shuttle

#	Compound	Targets Hit	Studies
1	Rotenone	—	300
2	Niclosamide	—	299
3	Adenosine Monophosphate Adenine nucleotide containing	—	300
4	Proguanil	—	299
5	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
6	Berberine	—	300
7	Ursolic Acid	—	300
8	Antimycin	—	300
9	Oleanolic Acid	—	300
10	Metformin	—	1,000
11	Dactinomycin	—	297
12	Retinaldehyde	—	300
13	Arachidonic Acid	—	245
14	Genistein	—	300
15	Quercetin	—	300
16	Ethidium	—	300
17	Dehydroepiandrosterone Sulfate	—	300
18	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
19	Sulindac	—	297
20	Thyroxine	—	994
21	Progesterone	—	299
22	Vitamin	—	295
23	Aldosterone	—	300
24	Calcitriol	—	300
25	Domperidone	—	299
26	Ethylene Chlorohydrin Used as	—	73
27	Phenol	—	297
28	Ribitol	—	297
29	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
30	Stavudine	—	298
31	Sulfanilamide	—	300
32	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
33	Thyroxine	—	300
34	Xylitol	—	300
35	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
36	Testosterone	—	299
37	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
38	Acetylcysteine	—	298
39	Adenosine	—	298
40	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
41	Chloral Hydrate	—	298
42	Chloralose	—	300
43	Cilostazol	—	297
44	Diflubenzuron	—	300
45	Dihydrotestosterone	—	300
46	dimethyl formamide	—	260
47	Dimethylformamide	—	300
48	Diuron	—	300
49	Ezetimibe	—	296
50	Flutamide	—	298

About the Carnitine shuttle Pathway

The Carnitine shuttle pathway is catalogued in Reactome (ID: R-HSA-200425) and involves 7 genes. In the BiohacksAI corpus, 96 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CPT2, PPARD, PRKAA2, PRKAB2, PRKAG2.