What compounds affect the ERKs are inactivated pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the ERKs are inactivated pathway (Reactome ID: R-HSA-202670). These compounds target 5 genes within this pathway.

What genes are in the ERKs are inactivated pathway?

The ERKs are inactivated pathway involves 5 genes. Key genes include: DUSP3, MAPK1, MAPK3, MAPK7, PPP2CA.

ERKs are inactivated

REACTOME PATHWAY

Reactome: R-HSA-2026705 genes28 compounds

The ERKs are inactivated pathway (Reactome ID: R-HSA-202670) involves 5 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DUSP3 MAPK1 MAPK3 MAPK7 PPP2CA

Compounds Affecting ERKs are inactivated

#	Compound	Targets Hit	Studies
1	plumbagin [Supplementary Concept]	—	300
2	pd98059	—	7
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
6	Sorafenib	—	300
7	trametinib	—	296
8	withaferin	—	300
9	tyrphostin ag 1478	—	4
10	Clotrimazole	—	296
11	sp600125	—	117
12	fisetin	—	78
13	Progesterone	—	299
14	2-Chloroadenosine 2-Chloroadenosine.	—	300
15	Benzalkonium Compounds	—	299
16	Calcimycin	—	216
17	daph	—	2
18	Diphenhydramine	—	14
19	ha1004	—	4
20	Lithocholic Acid	—	300
21	Loratadine	—	296
22	trequinsin hydrochloride	—	1
23	DEAD-box RNA Helicases	—	169
24	Thioctic Acid	—	298
25	Oleanolic Acid	—	300
26	Thioctic Acid	—	300
27	Crizotinib	—	298
28	Okadaic Acid	—	300

About the ERKs are inactivated Pathway

The ERKs are inactivated pathway is catalogued in Reactome (ID: R-HSA-202670) and involves 5 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DUSP3, MAPK1, MAPK3, MAPK7, PPP2CA.