What compounds affect the Synthesis of 5-eicosatetraenoic acids pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of 5-eicosatetraenoic acids pathway (Reactome ID: R-HSA-2142688). These compounds target 4 genes within this pathway.

What genes are in the Synthesis of 5-eicosatetraenoic acids pathway?

The Synthesis of 5-eicosatetraenoic acids pathway involves 4 genes. Key genes include: ALOX5, GPX1, GPX4, PON1.

Synthesis of 5-eicosatetraenoic acids

REACTOME PATHWAY

Reactome: R-HSA-21426884 genes55 compounds

The Synthesis of 5-eicosatetraenoic acids pathway (Reactome ID: R-HSA-2142688) involves 4 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX5 GPX1 GPX4 PON1

Compounds Affecting Synthesis of 5-eicosatetraenoic acids

#	Compound	Targets Hit	Studies
1	amlexanox	—	96
2	Cefotetan	—	299
3	Cephaloglycin	—	102
4	Dipyrone	—	298
5	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
6	Masoprocol	—	300
7	stx64	—	2
8	Quercetin	—	300
9	cbd	—	298
10	obeticholic acid [Supplementary Concept]	—	271
11	Mepentol [Supplementary Concept]	—	184
12	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
13	Vitamin	—	295
14	Camptothecin	—	300
15	candesartan cilexetil [Supplementary Concept]	—	300
16	cannabidiol	—	296
17	Cisplatin	—	300
18	Ethoxyquin Antioxidant; also	—	180
19	gamma-Linolenic Acid	—	300
20	Gestrinone	—	221
21	Hexachlorophene	—	300
22	Lypressin	—	24
23	Methyldopa	—	297
24	Ornipressin	—	82
25	Trenbolone Acetate	—	300
26	Triiodothyronine	—	300
27	DEAD-box RNA Helicases	—	169
28	Thioctic Acid	—	298
29	vinpocetine	—	299
30	cefatrizine	—	114
31	Cefazolin	—	300
32	Cefdinir	—	298
33	Cefixime	—	300
34	Cefmenoxime	—	300
35	Cefoxitin	—	300
36	Cefpodoxime	—	299
37	Cefprozil	—	297
38	ceftazidime	—	300
39	Ceftibuten	—	299
40	Doxazosin	—	24
41	Irinotecan	—	298
42	silver sulfadiazine	—	299
43	Thioctic Acid	—	300
44	pterostilbene	—	299
45	piceatannol	—	300
46	butein	—	158
47	Celecoxib	—	295
48	caffeic acid	—	300
49	Kaempferols	—	300
50	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150

About the Synthesis of 5-eicosatetraenoic acids Pathway

The Synthesis of 5-eicosatetraenoic acids pathway is catalogued in Reactome (ID: R-HSA-2142688) and involves 4 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX5, GPX1, GPX4, PON1.