What genes are in the Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway?

The Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway involves 5 genes. Key genes include: ABCC1, ALOX15, ALOX5, LTA4H, MAPKAPK2.

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Q: What compounds affect the Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway?

51 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway (Reactome ID: R-HSA-2142691). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21426915 genes51 compounds

The Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway (Reactome ID: R-HSA-2142691) involves 5 genes and is affected by 51 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ALOX15 ALOX5 LTA4H MAPKAPK2

Compounds Affecting Synthesis of Leukotrienes (LT) and Eoxins (EX)

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Masoprocol	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Celecoxib	—	295
7	Kaempferols	—	300
8	Indomethacin	—	297
9	Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid.	—	300
10	fisetin	—	78
11	Arachidonic Acid	—	245
12	Aurintricarboxylic Acid	—	184
13	Dipyrone	—	298
14	Catechin	—	51
15	alpha-Linolenic Acid	—	300
16	brl 50481	—	5
17	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
18	Dactinomycin	—	297
19	dihydroxyflavone	—	256
20	Dihydroxyphenylalanine	—	300
21	Ethidium	—	300
22	ethopropazine hydrochloride	—	2
23	Ethoxyquin Antioxidant; also	—	180
24	Hexachlorophene	—	300
25	Iodoacetamide	—	300
26	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
27	Linoleic Acid	—	300
28	Procarbazine	—	299
29	Pseudoephedrine	—	298
30	Daunorubicin	—	298
31	Rimonabant	—	300
32	Kaempferols	—	300
33	Abacavir	—	295
34	Dehydroepiandrosterone Sulfate	—	300
35	Delavirdine	—	296
36	Emtricitabine	—	292
37	Flurandrenolone	—	65
38	Lamivudine	—	299
39	tiopronin	—	299
40	Triamcinolone	—	300
41	Triamcinolone Acetonide	—	300
42	pterostilbene	—	299
43	piceatannol	—	300
44	butein	—	158
45	caffeic acid	—	300
46	Resveratrol	—	298
47	Anthralin	—	299
48	Bufexamac	—	137
49	Adenosine Triphosphate	—	300
50	Afatinib	—	297

About the Synthesis of Leukotrienes (LT) and Eoxins (EX) Pathway

The Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway is catalogued in Reactome (ID: R-HSA-2142691) and involves 5 genes. In the BiohacksAI corpus, 51 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ALOX15, ALOX5, LTA4H, MAPKAPK2.