What compounds affect the Biosynthesis of Lipoxins (LX) pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of Lipoxins (LX) pathway (Reactome ID: R-HSA-2142700). These compounds target 3 genes within this pathway.

What genes are in the Biosynthesis of Lipoxins (LX) pathway?

The Biosynthesis of Lipoxins (LX) pathway involves 3 genes. Key genes include: ALOX12, ALOX5, HPGD.

Biosynthesis of Lipoxins (LX)

REACTOME PATHWAY

Reactome: R-HSA-21427003 genes55 compounds

The Biosynthesis of Lipoxins (LX) pathway (Reactome ID: R-HSA-2142700) involves 3 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX12 ALOX5 HPGD

Compounds Affecting Biosynthesis of Lipoxins (LX)

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Masoprocol	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	butein	—	158
5	Disulfiram	—	297
6	Hexachlorophene	—	300
7	piceatannol	—	300
8	Kaempferols	—	300
9	Indomethacin	—	297
10	fisetin	—	78
11	Tyrosine	—	43
12	Tyrosine	—	300
13	celastrol	—	300
14	Chlorhexidine	—	299
15	Ciclopirox	—	88
16	Diiodotyrosine	—	300
17	Epinephrine	—	299
18	Flecainide	—	297
19	Fomepizole	—	298
20	Gliclazide	—	300
21	isoetharine	—	112
22	Kynurenic Acid	—	300
23	mg624	—	3
24	Phenelzine	—	297
25	Piribedil	—	300
26	Procarbazine	—	299
27	Rimonabant	—	300
28	scriptaid	—	53
29	Dipyrone	—	298
30	ethopropazine hydrochloride	—	2
31	Genistein	—	300
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
33	Carmine Coloring matter from	—	300
34	Sulfinpyrazone	—	300
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	Carbidopa	—	298
37	pd98059	—	7
38	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
39	Arachidonic Acid	—	245
40	plumbagin [Supplementary Concept]	—	300
41	salvin [Supplementary Concept]	—	300
42	DEET	—	298
43	diallyl trisulfide	—	246
44	Ethidium	—	300
45	hydroxyindoleacetic acid	—	300
46	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
47	Linoleic Acid	—	300
48	Niflumic Acid	—	300
49	pterostilbene	—	299
50	Celecoxib	—	295

About the Biosynthesis of Lipoxins (LX) Pathway

The Biosynthesis of Lipoxins (LX) pathway is catalogued in Reactome (ID: R-HSA-2142700) and involves 3 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX12, ALOX5, HPGD.