Synthesis of 12-eicosatetraenoic acid derivatives

Q: What compounds affect the Synthesis of 12-eicosatetraenoic acid derivatives pathway?

84 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of 12-eicosatetraenoic acid derivatives pathway (Reactome ID: R-HSA-2142712). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21427124 genes84 compounds

The Synthesis of 12-eicosatetraenoic acid derivatives pathway (Reactome ID: R-HSA-2142712) involves 4 genes and is affected by 84 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX12 ALOX15 GPX1 GPX4

Compounds Affecting Synthesis of 12-eicosatetraenoic acid derivatives

#	Compound	Targets Hit	Studies
1	Dipyrone	—	298
2	Masoprocol	—	300
3	Hexachlorophene	—	300
4	Quercetin	—	300
5	fisetin	—	78
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Procarbazine	—	299
8	ethopropazine hydrochloride	—	2
9	Ethoxyquin Antioxidant; also	—	180
10	amlexanox	—	96
11	Cefotetan	—	299
12	Cephaloglycin	—	102
13	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
14	stx64	—	2
15	Tyrosine	—	43
16	Tyrosine	—	300
17	butein	—	158
18	celastrol	—	300
19	Chlorhexidine	—	299
20	Ciclopirox	—	88
21	Diiodotyrosine	—	300
22	Disulfiram	—	297
23	Epinephrine	—	299
24	Flecainide	—	297
25	Fomepizole	—	298
26	Gliclazide	—	300
27	isoetharine	—	112
28	Kynurenic Acid	—	300
29	mg624	—	3
30	Phenelzine	—	297
31	piceatannol	—	300
32	Piribedil	—	300
33	Rimonabant	—	300
34	scriptaid	—	53
35	Arachidonic Acid	—	245
36	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
37	Aurintricarboxylic Acid	—	184
38	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
39	Catechin	—	51
40	alpha-Linolenic Acid	—	300
41	brl 50481	—	5
42	Celecoxib	—	295
43	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
44	Dactinomycin	—	297
45	dihydroxyflavone	—	256
46	Dihydroxyphenylalanine	—	300
47	Ethidium	—	300
48	Iodoacetamide	—	300
49	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
50	Linoleic Acid	—	300

About the Synthesis of 12-eicosatetraenoic acid derivatives Pathway

The Synthesis of 12-eicosatetraenoic acid derivatives pathway is catalogued in Reactome (ID: R-HSA-2142712) and involves 4 genes. In the BiohacksAI corpus, 84 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX12, ALOX15, GPX1, GPX4.