Synthesis of 15-eicosatetraenoic acid derivatives

Q: What compounds affect the Synthesis of 15-eicosatetraenoic acid derivatives pathway?

110 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of 15-eicosatetraenoic acid derivatives pathway (Reactome ID: R-HSA-2142770). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21427705 genes110 compounds

The Synthesis of 15-eicosatetraenoic acid derivatives pathway (Reactome ID: R-HSA-2142770) involves 5 genes and is affected by 110 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX15 ALOX15B GPX1 GPX4 PTGS2

Compounds Affecting Synthesis of 15-eicosatetraenoic acid derivatives

#	Compound	Targets Hit	Studies
1	Dipyrone	—	298
2	Quercetin	—	300
3	Masoprocol	—	300
4	Ethoxyquin Antioxidant; also	—	180
5	Hexachlorophene	—	300
6	Celecoxib	—	295
7	Arachidonic Acid	—	245
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	cbd	—	298
10	cannabidiol	—	296
11	Methyldopa	—	297
12	Procarbazine	—	299
13	Troglitazone	—	299
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Aurintricarboxylic Acid	—	184
16	alpha-Linolenic Acid	—	300
17	ethopropazine hydrochloride	—	2
18	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
19	Pseudoephedrine	—	298
20	amlexanox	—	96
21	Cefotetan	—	299
22	Cephaloglycin	—	102
23	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
24	stx64	—	2
25	Indomethacin	—	297
26	ns398	—	116
27	Meloxicam	—	299
28	Naproxen	—	1,000
29	Resveratrol	—	298
30	Etodolac	—	296
31	sulindac sulfide	—	79
32	pterostilbene	—	299
33	aphs	—	7
34	Oxaprozin	—	181
35	sc560	—	13
36	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
37	Ursolic Acid	—	300
38	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
39	Acetylcysteine	—	298
40	butein	—	158
41	Calcitriol	—	300
42	Cephradine	—	298
43	Daunorubicin	—	298
44	Epinephrine	—	299
45	Ergotamine	—	299
46	Hesperidin	—	300
47	Indapamide	—	299
48	isoetharine	—	112
49	Lymecycline	—	143
50	monorden	—	8

About the Synthesis of 15-eicosatetraenoic acid derivatives Pathway

The Synthesis of 15-eicosatetraenoic acid derivatives pathway is catalogued in Reactome (ID: R-HSA-2142770) and involves 5 genes. In the BiohacksAI corpus, 110 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX15, ALOX15B, GPX1, GPX4, PTGS2.