Condensation of Prophase Chromosomes
REACTOME PATHWAYThe Condensation of Prophase Chromosomes pathway (Reactome ID: R-HSA-2299718) involves 4 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Condensation of Prophase Chromosomes
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | alsterpaullone | — | 12 |
| 3 | indirubin | — | 300 |
| 4 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 5 | chrysin | — | 300 |
| 6 | fisetin | — | 78 |
| 7 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 8 | Quercetin | — | 300 |
| 9 | Clofibrate | — | 299 |
| 10 | Fenofibrate | — | 297 |
| 11 | Sertraline | — | 1,000 |
| 12 | Cinnarizine | — | 299 |
| 13 | Clotrimazole | — | 296 |
| 14 | Rotenone | — | 300 |
| 15 | Sorafenib | — | 300 |
| 16 | sp600125 | — | 117 |
| 17 | ly294002 | — | 11 |
| 18 | Wortmannin | — | 300 |
| 19 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 20 | Oleic Acid | — | 112 |
| 21 | Simvastatin | — | 1,000 |
| 22 | cefaclor | — | 299 |
| 23 | Disulfiram | — | 297 |
| 24 | Hexachlorophene | — | 300 |
| 25 | Lithocholic Acid | — | 300 |
| 26 | Nisoldipine | — | 297 |
| 27 | Oxyphenbutazone | — | 300 |
| 28 | Oxytetracycline | — | 300 |
| 29 | Cyproheptadine | — | 299 |
About the Condensation of Prophase Chromosomes Pathway
The Condensation of Prophase Chromosomes pathway is catalogued in Reactome (ID: R-HSA-2299718) and involves 4 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CDK1, KMT5A, PLK1.