What genes are in the DNA Damage/Telomere Stress Induced Senescence pathway?

The DNA Damage/Telomere Stress Induced Senescence pathway involves 5 genes. Key genes include: ATM, CCNA1, CCNE2, CDK2, TP53.

DNA Damage/Telomere Stress Induced Senescence

Q: What compounds affect the DNA Damage/Telomere Stress Induced Senescence pathway?

156 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Damage/Telomere Stress Induced Senescence pathway (Reactome ID: R-HSA-2559586). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-25595865 genes156 compounds

The DNA Damage/Telomere Stress Induced Senescence pathway (Reactome ID: R-HSA-2559586) involves 5 genes and is affected by 156 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM CCNA1 CCNE2 CDK2 TP53

Compounds Affecting DNA Damage/Telomere Stress Induced Senescence

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	Methylene Blue	—	200
5	Adenosine Triphosphate	—	300
6	Ethidium	—	300
7	Ethinyl Estradiol	—	300
8	Hexachlorophene	—	300
9	Azacitidine	—	298
10	Azacitidine	—	300
11	Bortezomib	—	300
12	Rotenone	—	300
13	Azathioprine	—	300
14	Cladribine	—	297
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
17	Cytarabine	—	297
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Melphalan	—	300
20	Niclosamide	—	299
21	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
22	Methotrexate	—	289
23	Dactinomycin	—	297
24	Daunorubicin	—	298
25	Disulfiram	—	297
26	Glutaral	—	42
27	Vitamin K 3	—	300
28	Trifluridine	—	295
29	Quercetin	—	300
30	Axitinib	—	298
31	ninhydrin	—	300
32	o-Phthalaldehyde	—	300
33	Razoxane	—	154
34	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
35	plumbagin [Supplementary Concept]	—	300
36	Camptothecin	—	300
37	Reserpine	—	297
38	Genistein	—	300
39	Resveratrol	—	298
40	Ciclopirox	—	88
41	Clofarabine	—	298
42	cycloheximide	—	300
43	daph	—	2
44	Dinitrochlorobenzene	—	300
45	Estramustine	—	300
46	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
47	Loratadine	—	296
48	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
49	Riluzole	—	298
50	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242

About the DNA Damage/Telomere Stress Induced Senescence Pathway

The DNA Damage/Telomere Stress Induced Senescence pathway is catalogued in Reactome (ID: R-HSA-2559586) and involves 5 genes. In the BiohacksAI corpus, 156 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, CCNA1, CCNE2, CDK2, TP53.