What compounds affect the Nuclear Envelope (NE) Reassembly pathway?

35 compounds in the BiohacksAI corpus have documented interactions with genes in the Nuclear Envelope (NE) Reassembly pathway (Reactome ID: R-HSA-2995410). These compounds target 26 genes within this pathway.

What genes are in the Nuclear Envelope (NE) Reassembly pathway?

The Nuclear Envelope (NE) Reassembly pathway involves 26 genes. Key genes include: CCNB1, CCNB2, CDK1, KPNB1, LMNA, PPP2CA, RAN, SIRT2, SUMO1, TUBA1A.

Nuclear Envelope (NE) Reassembly

REACTOME PATHWAY

Reactome: R-HSA-299541026 genes35 compounds

The Nuclear Envelope (NE) Reassembly pathway (Reactome ID: R-HSA-2995410) involves 26 genes and is affected by 35 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNB1 CCNB2 CDK1 KPNB1 LMNA PPP2CA RAN SIRT2 SUMO1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B

Compounds Affecting Nuclear Envelope (NE) Reassembly

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	kenpaullone	—	8
11	alsterpaullone	—	12
12	indirubin	—	300
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	chrysin	—	300
15	fisetin	—	78
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Reserpine	—	297
18	Clofibrate	—	299
19	Fenofibrate	—	297
20	Sertraline	—	1,000
21	Cinnarizine	—	299
22	Clotrimazole	—	296
23	Rotenone	—	300
24	Quercetin	—	300
25	Sorafenib	—	300
26	sp600125	—	117
27	Cefdinir	—	298
28	Cefixime	—	300
29	Hexachlorophene	—	300
30	Oxytetracycline	—	300
31	Chlorhexidine	—	299
32	Suramin	—	300
33	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
34	Histamine	—	300
35	Okadaic Acid	—	300

About the Nuclear Envelope (NE) Reassembly Pathway

The Nuclear Envelope (NE) Reassembly pathway is catalogued in Reactome (ID: R-HSA-2995410) and involves 26 genes. In the BiohacksAI corpus, 35 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CCNB2, CDK1, KPNB1, LMNA.