Non-integrin membrane-ECM interactions
REACTOME PATHWAYThe Non-integrin membrane-ECM interactions pathway (Reactome ID: R-HSA-3000171) involves 6 genes and is affected by 23 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Non-integrin membrane-ECM interactions
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Dasatinib | — | 299 |
| 3 | Axitinib | — | 298 |
| 4 | Crizotinib | — | 298 |
| 5 | Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in | — | 299 |
| 6 | Niflumic Acid | — | 300 |
| 7 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 8 | Thyroxine | — | 994 |
| 9 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 10 | pterostilbene | — | 299 |
| 11 | piceatannol | — | 300 |
| 12 | Thyroxine | — | 300 |
| 13 | egcg | — | 300 |
| 14 | Masoprocol | — | 300 |
| 15 | Genistein | — | 300 |
| 16 | Kaempferols | — | 300 |
| 17 | Resveratrol | — | 298 |
| 18 | Rosmarinic Acid | — | 300 |
| 19 | Vitamin | — | 295 |
| 20 | Dextrothyroxine | — | 134 |
| 21 | Gemfibrozil | — | 297 |
| 22 | Triiodothyronine | — | 300 |
| 23 | Dactinomycin | — | 297 |
About the Non-integrin membrane-ECM interactions Pathway
The Non-integrin membrane-ECM interactions pathway is catalogued in Reactome (ID: R-HSA-3000171) and involves 6 genes. In the BiohacksAI corpus, 23 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASK, DDR1, DDR2, ITGAV, ITGB3.