What compounds affect the HATs acetylate histones pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the HATs acetylate histones pathway (Reactome ID: R-HSA-3214847). These compounds target 6 genes within this pathway.

What genes are in the HATs acetylate histones pathway?

The HATs acetylate histones pathway involves 6 genes. Key genes include: CREBBP, EP300, KAT2A, KAT2B, NCOA1, WDR5.

HATs acetylate histones

REACTOME PATHWAY

Reactome: R-HSA-32148476 genes43 compounds

The HATs acetylate histones pathway (Reactome ID: R-HSA-3214847) involves 6 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 KAT2A KAT2B NCOA1 WDR5

Compounds Affecting HATs acetylate histones

#	Compound	Targets Hit	Studies
1	plumbagin [Supplementary Concept]	—	300
2	egcg	—	300
3	Aurintricarboxylic Acid	—	184
4	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
5	DEAD-box RNA Helicases	—	169
6	Thioctic Acid	—	298
7	Arachidonic Acid	—	245
8	Oleic Acid	—	112
9	alpha-Linolenic Acid	—	300
10	candesartan cilexetil [Supplementary Concept]	—	300
11	Cisplatin	—	300
12	diallyl trisulfide	—	246
13	Estramustine	—	300
14	gamma-Linolenic Acid	—	300
15	Hexachlorophene	—	300
16	Iodoacetamide	—	300
17	Lithocholic Acid	—	300
18	Oxytetracycline	—	300
19	rafoxanide	—	172
20	Ritonavir	—	298
21	Thioctic Acid	—	300
22	Trazodone	—	297
23	Methylene Blue	—	200
24	Anisomycin	—	247
25	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
26	Digoxin	—	299
27	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
28	Tubercidin	—	300
29	Methotrexate	—	289
30	Azacitidine	—	298
31	Azacitidine	—	300
32	cycloheximide	—	300
33	Famotidine	—	296
34	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
35	Trifluridine	—	295
36	urolithin b	—	49
37	Papaverine	—	299
38	Colchicine	—	300
39	Etazolate	—	66
40	Nocodazole Nocodazole is	—	215
41	11-hydroxypalmatine [Supplementary Concept]	—	238
42	np1	—	81
43	s adenosylhomocysteine	—	300

About the HATs acetylate histones Pathway

The HATs acetylate histones pathway is catalogued in Reactome (ID: R-HSA-3214847) and involves 6 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, KAT2A, KAT2B, NCOA1.