What genes are in the Regulation of HSF1-mediated heat shock response pathway?

The Regulation of HSF1-mediated heat shock response pathway involves 10 genes. Key genes include: ATM, GSK3B, HSPA1A, HSPA1B, HSPA5, HSPA8, MAPK1, MAPK3, MAPKAPK2, SIRT1.

Regulation of HSF1-mediated heat shock response

Q: What compounds affect the Regulation of HSF1-mediated heat shock response pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of HSF1-mediated heat shock response pathway (Reactome ID: R-HSA-3371453). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-337145310 genes45 compounds

The Regulation of HSF1-mediated heat shock response pathway (Reactome ID: R-HSA-3371453) involves 10 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM GSK3B HSPA1A HSPA1B HSPA5 HSPA8 MAPK1 MAPK3 MAPKAPK2 SIRT1

Compounds Affecting Regulation of HSF1-mediated heat shock response

#	Compound	Targets Hit	Studies
1	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
2	Ergosterol	—	300
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Sorafenib	—	300
6	Adenosine Triphosphate	—	300
7	plumbagin [Supplementary Concept]	—	300
8	pd98059	—	7
9	sp600125	—	117
10	fisetin	—	78
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	trametinib	—	296
13	withaferin	—	300
14	Hexachlorophene	—	300
15	tyrphostin ag 1478	—	4
16	Clotrimazole	—	296
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	indirubin	—	300
28	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
29	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
30	Kaempferols	—	300
31	Quercetin	—	300
32	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
33	Lithium Chloride	—	300
34	chrysin	—	300
35	ly294002	—	11
36	egcg	—	300
37	Rutin	—	300
38	Ursolic Acid	—	300
39	Oleanolic Acid	—	300
40	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
41	Methylene Blue	—	200
42	streptonigrin	—	299
43	Suramin	—	300
44	Resveratrol	—	298
45	Afatinib	—	297

About the Regulation of HSF1-mediated heat shock response Pathway

The Regulation of HSF1-mediated heat shock response pathway is catalogued in Reactome (ID: R-HSA-3371453) and involves 10 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, GSK3B, HSPA1A, HSPA1B, HSPA5.