What genes are in the Autodegradation of the E3 ubiquitin ligase COP1 pathway?

The Autodegradation of the E3 ubiquitin ligase COP1 pathway involves 34 genes. Key genes include: ADRM1, ATM, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1.

Autodegradation of the E3 ubiquitin ligase COP1

Q: What compounds affect the Autodegradation of the E3 ubiquitin ligase COP1 pathway?

157 compounds in the BiohacksAI corpus have documented interactions with genes in the Autodegradation of the E3 ubiquitin ligase COP1 pathway (Reactome ID: R-HSA-349425). These compounds target 34 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-34942534 genes157 compounds

The Autodegradation of the E3 ubiquitin ligase COP1 pathway (Reactome ID: R-HSA-349425) involves 34 genes and is affected by 157 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ATM PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6+4 more

Compounds Affecting Autodegradation of the E3 ubiquitin ligase COP1

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	Methylene Blue	—	200
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Disulfiram	—	297
7	Quercetin	—	300
8	Genistein	—	300
9	chrysin	—	300
10	Harmaline	—	300
11	Ethidium	—	300
12	Ethinyl Estradiol	—	300
13	Hexachlorophene	—	300
14	Azacitidine	—	298
15	Azacitidine	—	300
16	Rotenone	—	300
17	Azathioprine	—	300
18	Cladribine	—	297
19	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
20	Cytarabine	—	297
21	Melphalan	—	300
22	Niclosamide	—	299
23	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
24	Methotrexate	—	289
25	Dactinomycin	—	297
26	Daunorubicin	—	298
27	Glutaral	—	42
28	Vitamin K 3	—	300
29	Trifluridine	—	295
30	Axitinib	—	298
31	ninhydrin	—	300
32	o-Phthalaldehyde	—	300
33	Razoxane	—	154
34	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
35	plumbagin [Supplementary Concept]	—	300
36	Camptothecin	—	300
37	Resveratrol	—	298
38	Ciclopirox	—	88
39	Clofarabine	—	298
40	cycloheximide	—	300
41	daph	—	2
42	Dinitrochlorobenzene	—	300
43	Estramustine	—	300
44	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
45	Loratadine	—	296
46	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
47	Riluzole	—	298
48	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
49	Trabectedin	—	297
50	Vorinostat	—	299

About the Autodegradation of the E3 ubiquitin ligase COP1 Pathway

The Autodegradation of the E3 ubiquitin ligase COP1 pathway is catalogued in Reactome (ID: R-HSA-349425) and involves 34 genes. In the BiohacksAI corpus, 157 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ATM, PSMA1, PSMA2, PSMA3.