What compounds affect the Netrin-1 signaling pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Netrin-1 signaling pathway (Reactome ID: R-HSA-373752). These compounds target 5 genes within this pathway.

What genes are in the Netrin-1 signaling pathway?

The Netrin-1 signaling pathway involves 5 genes. Key genes include: CDC42, FYN, SRC, TRPC5, TRPC6.

Netrin-1 signaling

REACTOME PATHWAY

Reactome: R-HSA-3737525 genes36 compounds

The Netrin-1 signaling pathway (Reactome ID: R-HSA-373752) involves 5 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC42 FYN SRC TRPC5 TRPC6

Compounds Affecting Netrin-1 signaling

#	Compound	Targets Hit	Studies
1	Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes	—	300
2	Dasatinib	—	299
3	tyrphostin ag 1478	—	4
4	Sorafenib	—	300
5	Quercetin	—	300
6	Crizotinib	—	298
7	kenpaullone	—	8
8	Genistein	—	300
9	Hyoscyamine	—	296
10	Carvedilol	—	296
11	Propantheline	—	73
12	Methylene Blue	—	200
13	Hexachlorophene	—	300
14	Promazine	—	40
15	Promethazine	—	121
16	propionylpromazine hydrochloride	—	2
17	Thioridazine	—	35
18	triflupromazine hydrochloride	—	12
19	Arachidonic Acid	—	245
20	Duloxetine Hydrochloride	—	993
21	Amoxapine	—	259
22	Fluspirilene	—	74
23	Resveratrol	—	298
24	Adenosine Monophosphate Adenine nucleotide containing	—	300
25	Afatinib	—	297
26	alsterpaullone	—	12
27	monorden	—	8
28	Niclosamide	—	299
29	Rosmarinic Acid	—	300
30	egcg	—	300
31	Acetic Acid Product of	—	300
32	Pueraria	—	300
33	Kaempferols	—	300
34	Progesterone	—	299
35	m084	—	2
36	casin	—	10

About the Netrin-1 signaling Pathway

The Netrin-1 signaling pathway is catalogued in Reactome (ID: R-HSA-373752) and involves 5 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC42, FYN, SRC, TRPC5, TRPC6.