What compounds affect the PERK regulates gene expression pathway?

22 compounds in the BiohacksAI corpus have documented interactions with genes in the PERK regulates gene expression pathway (Reactome ID: R-HSA-381042). These compounds target 5 genes within this pathway.

What genes are in the PERK regulates gene expression pathway?

The PERK regulates gene expression pathway involves 5 genes. Key genes include: ATF6, CCL2, CXCL8, EIF2AK3, HSPA5.

PERK regulates gene expression

REACTOME PATHWAY

Reactome: R-HSA-3810425 genes22 compounds

The PERK regulates gene expression pathway (Reactome ID: R-HSA-381042) involves 5 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATF6 CCL2 CXCL8 EIF2AK3 HSPA5

Compounds Affecting PERK regulates gene expression

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Vitamin	—	295
3	Bromodeoxyuridine	—	300
4	Dacarbazine	—	299
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Ethinyl Estradiol	—	300
7	Indomethacin	—	297
8	Retinaldehyde	—	300
9	Tolmetin	—	298
10	Toxaphene	—	299
11	fluoranthene	—	300
12	Ethoxyquin Antioxidant; also	—	180
13	Methylcholanthrene	—	300
14	Mometasone Furoate	—	292
15	Masoprocol	—	300
16	aniracetam	—	110
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Camptothecin	—	300
19	Hexachlorophene	—	300
20	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
21	Ergosterol	—	300
22	hydroxyfasudil [Supplementary Concept]	—	11

About the PERK regulates gene expression Pathway

The PERK regulates gene expression pathway is catalogued in Reactome (ID: R-HSA-381042) and involves 5 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATF6, CCL2, CXCL8, EIF2AK3, HSPA5.