What compounds target CXCL8?

BiohacksAI has identified 132 compounds that interact with CXCL8 (C-X-C motif chemokine ligand 8). Top compounds include: diclofenac, Colchicine, achyranthes bidentata, agastache rugosa, Garlic. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CXCL8 (C-X-C motif chemokine)?

CXCL8 is C-X-C motif chemokine ligand 8. It is a molecular target for 132 compounds documented in PubMed bioassay data. UniProt ID: P10145. NCBI Gene ID: 3576.

CXCL8

MOLECULAR TARGET

C-X-C motif chemokine ligand 8

UniProt: P10145 NCBI Gene: 3576132 compounds

CXCL8 (C-X-C motif chemokine ligand 8) is targeted by 132 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CXCL8

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	diclofenac	5.66	285
2	Colchicine	1.10	2
3	achyranthes bidentata	1.00	1
4	agastache rugosa	1.00	1
5	Garlic	1.00	1
6	allium tuberosum	1.00	1
7	aloe vera	1.00	1
8	anemarrhena asphodeloides	1.00	1
9	apis mellifera	1.00	1
10	arctium lappa	1.00	1
11	artemisia annua	1.00	1
12	artemisia argyi	1.00	1
13	artemisia capillaris	1.00	1
14	aster tataricus	1.00	1
15	atractylodes macrocephala	1.00	1
16	bletilla striata	1.00	1
17	bufo bufo	1.00	1
18	bupleurum chinense	1.00	1
19	carthamus tinctorius	1.00	1
20	Centella	1.00	1
21	chaenomeles speciosa	1.00	1
22	citrus reticulata	1.00	1
23	crataegus pinnatifida	1.00	1
24	curculigo orchioides	1.00	1
25	Curcuma	1.00	1
26	cuscuta chinensis	1.00	1
27	cynomorium songaricum	1.00	1
28	dimocarpus longan	1.00	1
29	ephedra sinica	1.00	1
30	epimedium brevicornum	1.00	1
31	eriobotrya japonica	1.00	1
32	eucommia ulmoides	1.00	1
33	eupatorium fortunei	1.00	1
34	Foeniculum	1.00	1
35	forsythia suspensa	1.00	1
36	fritillaria cirrhosa	1.00	1
37	gastrodia elata	1.00	1
38	Ginkgo biloba	1.00	1
39	glycine max	1.00	1
40	glycyrrhiza uralensis	1.00	1
41	inula japonica	1.00	1
42	ligusticum chuanxiong	1.00	1
43	lilium lancifolium	1.00	1
44	litchi chinensis	1.00	1
45	lithospermum erythrorhizon	1.00	1
46	lobelia chinensis	1.00	1
47	lonicera japonica	1.00	1
48	magnolia biondii	1.00	1
49	morus alba	1.00	1
50	Nelumbo	1.00	1

Showing top 50 of 132 compounds. Use the BiohacksAI search to explore all CXCL8 modulators.

About CXCL8 as a Drug Target

CXCL8 (C-X-C motif chemokine ligand 8) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 132 compounds with documented CXCL8 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CXCL8 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.