Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Q: What compounds affect the Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway?

61 compounds in the BiohacksAI corpus have documented interactions with genes in the Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway (Reactome ID: R-HSA-381676). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3816768 genes61 compounds

The Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway (Reactome ID: R-HSA-381676) involves 8 genes and is affected by 61 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GLP1R GNAS KCNB1 PRKACA PRKACB PRKACG RAPGEF3 RAPGEF4

Compounds Affecting Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Clotrimazole	—	296
3	Cyclic AMP	—	300
4	Cyclic AMP	—	300
5	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
6	Idarubicin	—	299
7	Trapidil	—	292
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	Hexachlorophene	—	300
10	Arachidonic Acid	—	245
11	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
12	Aurintricarboxylic Acid	—	184
13	candesartan cilexetil [Supplementary Concept]	—	300
14	Daunorubicin	—	298
15	Dihydroxyphenylalanine	—	300
16	Evans Blue	—	300
17	Masoprocol	—	300
18	Perphenazine	—	297
19	Farnesol	—	300
20	Nitrendipine	—	299
21	trequinsin hydrochloride	—	1
22	Resveratrol	—	298
23	Alprostadil	—	297
24	Amaranth Dye	—	48
25	Antimycin	—	300
26	ethopropazine hydrochloride	—	2
27	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
28	Loratadine	—	296
29	Nocodazole Nocodazole is	—	215
30	Piperonyl Butoxide	—	300
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
32	rafoxanide	—	172
33	Night Vision Function of	—	56
34	Quercetin	—	300
35	Bromocriptine	—	299
36	cardamonin	—	180
37	Catechin	—	300
38	Ethynodiol Diacetate	—	300
39	Tocainide	—	299
40	Troglitazone	—	299
41	Liraglutide	—	999
42	Levalbuterol	—	1,000
43	Semaglutide	—	999
44	2-Methoxyestradiol	—	300
45	Levalbuterol	—	297
46	Azauridine	—	300
47	cycloheximide	—	300
48	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
49	Dihydroergotamine	—	9
50	Ethidium	—	300

About the Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Pathway

The Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway is catalogued in Reactome (ID: R-HSA-381676) and involves 8 genes. In the BiohacksAI corpus, 61 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GLP1R, GNAS, KCNB1, PRKACA, PRKACB.