What compounds affect the ABC-family proteins mediated transport pathway?

234 compounds in the BiohacksAI corpus have documented interactions with genes in the ABC-family proteins mediated transport pathway (Reactome ID: R-HSA-382556). These compounds target 42 genes within this pathway.

What genes are in the ABC-family proteins mediated transport pathway?

The ABC-family proteins mediated transport pathway involves 42 genes. Key genes include: ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCC9, ADRM1, CFTR.

ABC-family proteins mediated transport

REACTOME PATHWAY

Reactome: R-HSA-38255642 genes234 compounds

The ABC-family proteins mediated transport pathway (Reactome ID: R-HSA-382556) involves 42 genes and is affected by 234 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB1 ABCB6 ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCC9 ADRM1 CFTR PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6+12 more

Compounds Affecting ABC-family proteins mediated transport

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Delavirdine	—	296
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Glyburide	—	298
6	Rimonabant	—	300
7	egcg	—	300
8	Quercetin	—	300
9	Bumetanide	—	299
10	Disulfiram	—	297
11	Hexachlorophene	—	300
12	Abacavir	—	295
13	cefaclor	—	299
14	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
15	Cefmetazole	—	300
16	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
17	Cefoxitin	—	300
18	Ceftriaxone	—	299
19	cefuroxime	—	299
20	Cephradine	—	298
21	Emtricitabine	—	292
22	Lamivudine	—	299
23	Clotrimazole	—	296
24	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
25	Nocodazole Nocodazole is	—	215
26	Podophyllotoxin	—	14
27	Methotrexate	—	289
28	Anisomycin	—	247
29	cycloheximide	—	300
30	Daunorubicin	—	298
31	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
32	Digoxin	—	299
33	Niclosamide	—	299
34	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
35	Tubercidin	—	300
36	vinblastine sulfate	—	81
37	Budesonide	—	1,000
38	chrysin	—	300
39	Kaempferols	—	300
40	alsterpaullone	—	12
41	Carbazilquinone	—	48
42	Dinitrochlorobenzene	—	300
43	Dinoprostone	—	296
44	Doxazosin	—	24
45	Flumethasone	—	179
46	Indomethacin	—	297
47	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
48	Vitamin K 3	—	300
49	Methylprednisolone	—	299
50	Nisoldipine	—	297

About the ABC-family proteins mediated transport Pathway

The ABC-family proteins mediated transport pathway is catalogued in Reactome (ID: R-HSA-382556) and involves 42 genes. In the BiohacksAI corpus, 234 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB1, ABCB6, ABCC1, ABCC2, ABCC3.