What compounds affect the Rap1 signalling pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the Rap1 signalling pathway (Reactome ID: R-HSA-392517). These compounds target 7 genes within this pathway.

What genes are in the Rap1 signalling pathway?

The Rap1 signalling pathway involves 7 genes. Key genes include: PRKACA, PRKACB, PRKACG, RAF1, RAPGEF3, RAPGEF4, YWHAB.

Rap1 signalling

REACTOME PATHWAY

Reactome: R-HSA-3925177 genes45 compounds

The Rap1 signalling pathway (Reactome ID: R-HSA-392517) involves 7 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PRKACA PRKACB PRKACG RAF1 RAPGEF3 RAPGEF4 YWHAB

Compounds Affecting Rap1 signalling

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Cyclic AMP	—	300
3	Cyclic AMP	—	300
4	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
5	Idarubicin	—	299
6	Trapidil	—	292
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Hexachlorophene	—	300
9	Arachidonic Acid	—	245
10	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
11	Aurintricarboxylic Acid	—	184
12	candesartan cilexetil [Supplementary Concept]	—	300
13	Daunorubicin	—	298
14	Dihydroxyphenylalanine	—	300
15	Evans Blue	—	300
16	Masoprocol	—	300
17	Quercetin	—	300
18	Clotrimazole	—	296
19	Farnesol	—	300
20	Nitrendipine	—	299
21	trequinsin hydrochloride	—	1
22	Resveratrol	—	298
23	Alprostadil	—	297
24	Amaranth Dye	—	48
25	Antimycin	—	300
26	ethopropazine hydrochloride	—	2
27	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
28	Loratadine	—	296
29	Nocodazole Nocodazole is	—	215
30	Perphenazine	—	297
31	Piperonyl Butoxide	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	rafoxanide	—	172
34	Night Vision Function of	—	56
35	Bromocriptine	—	299
36	cardamonin	—	180
37	Catechin	—	300
38	Ethynodiol Diacetate	—	300
39	Tocainide	—	299
40	Troglitazone	—	299
41	Sorafenib	—	300
42	Vemurafenib	—	298
43	Dasatinib	—	299
44	alpelisib	—	227
45	Sphingosine	—	300

About the Rap1 signalling Pathway

The Rap1 signalling pathway is catalogued in Reactome (ID: R-HSA-392517) and involves 7 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PRKACA, PRKACB, PRKACG, RAF1, RAPGEF3.