Sema4D in semaphorin signaling
REACTOME PATHWAYThe Sema4D in semaphorin signaling pathway (Reactome ID: R-HSA-400685) involves 7 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Sema4D in semaphorin signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Crizotinib | — | 298 |
| 2 | Sorafenib | — | 300 |
| 3 | Dasatinib | — | 299 |
| 4 | Afatinib | — | 297 |
| 5 | sp600125 | — | 117 |
| 6 | kenpaullone | — | 8 |
| 7 | egcg | — | 300 |
| 8 | Axitinib | — | 298 |
| 9 | Quercetin | — | 300 |
| 10 | Adenosine Triphosphate | — | 300 |
| 11 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 12 | Kinetin | — | 300 |
| 13 | alsterpaullone | — | 12 |
| 14 | Edaravone | — | 298 |
| 15 | tyrphostin ag 1478 | — | 4 |
| 16 | Hydrocortisone | — | 299 |
| 17 | Hydrocortisone | — | 298 |
| 18 | Atorvastatin | — | 1,000 |
About the Sema4D in semaphorin signaling Pathway
The Sema4D in semaphorin signaling pathway is catalogued in Reactome (ID: R-HSA-400685) and involves 7 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, ERBB2, LIMK1, LIMK2, MET.