What compounds affect the Nucleotide-like (purinergic) receptors pathway?

59 compounds in the BiohacksAI corpus have documented interactions with genes in the Nucleotide-like (purinergic) receptors pathway (Reactome ID: R-HSA-418038). These compounds target 11 genes within this pathway.

What genes are in the Nucleotide-like (purinergic) receptors pathway?

The Nucleotide-like (purinergic) receptors pathway involves 11 genes. Key genes include: ADORA2B, ADORA3, GPR17, P2RY1, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY4.

Nucleotide-like (purinergic) receptors

REACTOME PATHWAY

Reactome: R-HSA-41803811 genes59 compounds

The Nucleotide-like (purinergic) receptors pathway (Reactome ID: R-HSA-418038) involves 11 genes and is affected by 59 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADORA2B ADORA3 GPR17 P2RY1 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6

Compounds Affecting Nucleotide-like (purinergic) receptors

#	Compound	Targets Hit	Studies
1	Adenosine Triphosphate	—	300
2	Suramin	—	300
3	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
4	Uridine Triphosphate Uridine 5'-(tetrahydrogen triphosphate).	—	300
5	Uridine Diphosphate Glucose	—	300
6	Ticagrelor	—	299
7	Uridine Diphosphate	—	300
8	Adenosine Monophosphate Adenine nucleotide containing	—	300
9	2-Chloroadenosine 2-Chloroadenosine.	—	300
10	Adenosine	—	298
11	Uridine Diphosphate Galactose	—	180
12	Leukotriene E4	—	300
13	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
14	Bromocriptine	—	299
15	Troglitazone	—	299
16	Kinetin	—	300
17	Quercetin	—	300
18	same	—	299
19	Simvastatin	—	1,000
20	Vitamin K 2	—	300
21	Aripiprazole	—	298
22	Axitinib	—	298
23	Calcitriol	—	300
24	candesartan cilexetil [Supplementary Concept]	—	300
25	Celecoxib	—	295
26	Chlorhexidine	—	299
27	cinacalcet	—	298
28	Clotrimazole	—	296
29	Crizotinib	—	298
30	Cyclizine	—	251
31	Dequalinium	—	136
32	Desogestrel	—	299
33	Disulfiram	—	297
34	Ethynodiol Diacetate	—	300
35	Ezetimibe	—	296
36	Flunarizine Flunarizine is	—	299
37	Fluspirilene	—	74
38	Hexachlorophene	—	300
39	Loratadine	—	296
40	Meclizine	—	121
41	Mometasone Furoate	—	292
42	Nisoldipine	—	297
43	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
44	Oxymetholone	—	298
45	Pentostatin	—	297
46	Rimonabant	—	300
47	s adenosylmethionine	—	300
48	Sorafenib	—	300
49	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
50	Thiethylperazine	—	165

About the Nucleotide-like (purinergic) receptors Pathway

The Nucleotide-like (purinergic) receptors pathway is catalogued in Reactome (ID: R-HSA-418038) and involves 11 genes. In the BiohacksAI corpus, 59 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADORA2B, ADORA3, GPR17, P2RY1, P2RY11.