What genes are in the NoRC negatively regulates rRNA expression pathway?

The NoRC negatively regulates rRNA expression pathway involves 7 genes. Key genes include: CDK7, DNMT1, DNMT3B, ERCC3, HDAC1, HDAC2, MBD2.

NoRC negatively regulates rRNA expression

Q: What compounds affect the NoRC negatively regulates rRNA expression pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the NoRC negatively regulates rRNA expression pathway (Reactome ID: R-HSA-427413). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4274137 genes41 compounds

The NoRC negatively regulates rRNA expression pathway (Reactome ID: R-HSA-427413) involves 7 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 DNMT1 DNMT3B ERCC3 HDAC1 HDAC2 MBD2

Compounds Affecting NoRC negatively regulates rRNA expression

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	Cefixime	—	300
3	s adenosylhomocysteine	—	300
4	Vorinostat	—	299
5	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
6	scriptaid	—	53
7	Valproic Acid	—	296
8	Butyric Acid	—	300
9	Ursolic Acid	—	300
10	Celecoxib	—	295
11	Daunorubicin	—	298
12	Bortezomib	—	300
13	Camptothecin	—	300
14	DEAD-box RNA Helicases	—	169
15	Thioctic Acid	—	298
16	Methylene Blue	—	200
17	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
18	Ethidium	—	300
19	Levodopa	—	297
20	Thioctic Acid	—	300
21	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
22	Demeclocycline	—	5
23	Didanosine	—	297
24	Dinitolmide	—	25
25	Edaravone	—	298
26	Ribitol	—	297
27	Xylitol	—	300
28	egcg	—	300
29	Oleic Acid	—	112
30	Anthralin	—	299
31	Azacitidine	—	298
32	Azacitidine	—	300
33	Carboxin	—	174
34	Cefdinir	—	298
35	Decitabine	—	298
36	Fluorometholone	—	299
37	Oxytetracycline	—	300
38	Uridine	—	300
39	hydroxyfasudil [Supplementary Concept]	—	11
40	Sorafenib	—	300
41	Tripterygium	—	300

About the NoRC negatively regulates rRNA expression Pathway

The NoRC negatively regulates rRNA expression pathway is catalogued in Reactome (ID: R-HSA-427413) and involves 7 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, DNMT1, DNMT3B, ERCC3, HDAC1.