CREB1 phosphorylation through the activation of Adenylate Cyclase

Q: What compounds affect the CREB1 phosphorylation through the activation of Adenylate Cyclase pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the CREB1 phosphorylation through the activation of Adenylate Cyclase pathway (Reactome ID: R-HSA-442720). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4427205 genes46 compounds

The CREB1 phosphorylation through the activation of Adenylate Cyclase pathway (Reactome ID: R-HSA-442720) involves 5 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 PRKACA PRKACB PRKACG PRKX

Compounds Affecting CREB1 phosphorylation through the activation of Adenylate Cyclase

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	cycloheximide	—	300
3	Disulfiram	—	297
4	Azacitidine	—	298
5	Azacitidine	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Levalbuterol	—	1,000
8	Adenosine Monophosphate Adenine nucleotide containing	—	300
9	Levalbuterol	—	297
10	Bortezomib	—	300
11	Clofarabine	—	298
12	Dactinomycin	—	297
13	Danazol	—	298
14	Emetine	—	298
15	Ethidium	—	300
16	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
17	Sulbactam	—	299
18	trequinsin hydrochloride	—	1
19	chrysin	—	300
20	Genistein	—	300
21	Quercetin	—	300
22	Testosterone	—	299
23	Ciclopirox	—	88
24	Cladribine	—	297
25	Clenbuterol	—	300
26	Corticosterone	—	300
27	Dasatinib	—	299
28	Daunorubicin	—	298
29	Dinoprostone	—	296
30	Epinephrine	—	299
31	Ethinyl Estradiol	—	300
32	Imatinib Mesylate	—	300
33	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
34	Nisoldipine	—	297
35	Nocodazole Nocodazole is	—	215
36	Masoprocol	—	300
37	Norepinephrine Precursor of epinephrine that is secreted by	—	298
38	o-Phthalaldehyde	—	300
39	Oxyphenbutazone	—	300
40	pivampicillin	—	275
41	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
42	Salmeterol Xinafoate	—	227
43	Tilorone	—	300
44	Urea	—	297
45	alpelisib	—	227
46	Sphingosine	—	300

About the CREB1 phosphorylation through the activation of Adenylate Cyclase Pathway

The CREB1 phosphorylation through the activation of Adenylate Cyclase pathway is catalogued in Reactome (ID: R-HSA-442720) and involves 5 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, PRKACA, PRKACB, PRKACG, PRKX.