Thrombin signalling through proteinase activated receptors (PARs)

Q: What compounds affect the Thrombin signalling through proteinase activated receptors (PARs) pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Thrombin signalling through proteinase activated receptors (PARs) pathway (Reactome ID: R-HSA-456926). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4569265 genes40 compounds

The Thrombin signalling through proteinase activated receptors (PARs) pathway (Reactome ID: R-HSA-456926) involves 5 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARRB1 GNA15 MAPK1 MAPK3 SRC

Compounds Affecting Thrombin signalling through proteinase activated receptors (PARs)

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	kenpaullone	—	8
3	Sorafenib	—	300
4	plumbagin [Supplementary Concept]	—	300
5	pd98059	—	7
6	tyrphostin ag 1478	—	4
7	Calcimycin	—	216
8	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
9	trametinib	—	296
10	withaferin	—	300
11	Clotrimazole	—	296
12	sp600125	—	117
13	fisetin	—	78
14	Progesterone	—	299
15	2-Chloroadenosine 2-Chloroadenosine.	—	300
16	Benzalkonium Compounds	—	299
17	daph	—	2
18	Diphenhydramine	—	14
19	ha1004	—	4
20	Lithocholic Acid	—	300
21	Loratadine	—	296
22	trequinsin hydrochloride	—	1
23	Dasatinib	—	299
24	Resveratrol	—	298
25	Quercetin	—	300
26	Adenosine Monophosphate Adenine nucleotide containing	—	300
27	Afatinib	—	297
28	Crizotinib	—	298
29	monorden	—	8
30	Niclosamide	—	299
31	Aripiprazole	—	298
32	Bisphenol A-Glycidyl Methacrylate	—	197
33	Equilin	—	216
34	Fluspirilene	—	74
35	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
36	Sphingosine	—	300
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	aniracetam	—	110
39	Nadolol	—	297
40	Nicardipine	—	94

About the Thrombin signalling through proteinase activated receptors (PARs) Pathway

The Thrombin signalling through proteinase activated receptors (PARs) pathway is catalogued in Reactome (ID: R-HSA-456926) and involves 5 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARRB1, GNA15, MAPK1, MAPK3, SRC.