Positive epigenetic regulation of rRNA expression

Q: What compounds affect the Positive epigenetic regulation of rRNA expression pathway?

60 compounds in the BiohacksAI corpus have documented interactions with genes in the Positive epigenetic regulation of rRNA expression pathway (Reactome ID: R-HSA-5250913). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-52509137 genes60 compounds

The Positive epigenetic regulation of rRNA expression pathway (Reactome ID: R-HSA-5250913) involves 7 genes and is affected by 60 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EHMT2 EP300 GSK3B HDAC1 HDAC2 KAT2A KAT2B

Compounds Affecting Positive epigenetic regulation of rRNA expression

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Ursolic Acid	—	300
3	Vorinostat	—	299
4	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
5	scriptaid	—	53
6	Valproic Acid	—	296
7	pictilisib	—	25
8	Butyric Acid	—	300
9	Celecoxib	—	295
10	Daunorubicin	—	298
11	Bortezomib	—	300
12	Camptothecin	—	300
13	plumbagin [Supplementary Concept]	—	300
14	Aurintricarboxylic Acid	—	184
15	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
16	DEAD-box RNA Helicases	—	169
17	Thioctic Acid	—	298
18	Arachidonic Acid	—	245
19	Oleic Acid	—	112
20	alpha-Linolenic Acid	—	300
21	candesartan cilexetil [Supplementary Concept]	—	300
22	Cisplatin	—	300
23	diallyl trisulfide	—	246
24	Estramustine	—	300
25	gamma-Linolenic Acid	—	300
26	Hexachlorophene	—	300
27	Iodoacetamide	—	300
28	Lithocholic Acid	—	300
29	Oxytetracycline	—	300
30	rafoxanide	—	172
31	Ritonavir	—	298
32	Thioctic Acid	—	300
33	Trazodone	—	297
34	alsterpaullone	—	12
35	kenpaullone	—	8
36	indirubin	—	300
37	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
38	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
39	Kaempferols	—	300
40	Quercetin	—	300
41	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
42	Lithium Chloride	—	300
43	chrysin	—	300
44	fisetin	—	78
45	ly294002	—	11
46	Sorafenib	—	300
47	Rutin	—	300
48	Oleanolic Acid	—	300
49	sp600125	—	117
50	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300

About the Positive epigenetic regulation of rRNA expression Pathway

The Positive epigenetic regulation of rRNA expression pathway is catalogued in Reactome (ID: R-HSA-5250913) and involves 7 genes. In the BiohacksAI corpus, 60 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EHMT2, EP300, GSK3B, HDAC1, HDAC2.