What genes are in the SLC-mediated transport of organic cations pathway?

The SLC-mediated transport of organic cations pathway involves 7 genes. Key genes include: RUNX1, SLC22A1, SLC22A3, SLC22A4, SLC22A5, SLC47A1, SLC47A2.

SLC-mediated transport of organic cations

Q: What compounds affect the SLC-mediated transport of organic cations pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the SLC-mediated transport of organic cations pathway (Reactome ID: R-HSA-549127). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-5491277 genes45 compounds

The SLC-mediated transport of organic cations pathway (Reactome ID: R-HSA-549127) involves 7 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

RUNX1 SLC22A1 SLC22A3 SLC22A4 SLC22A5 SLC47A1 SLC47A2

Compounds Affecting SLC-mediated transport of organic cations

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	pentamidine	—	299
3	Cimetidine	—	299
4	Progesterone	—	299
5	Corticosterone	—	300
6	Ondansetron	—	299
7	Irinotecan	—	298
8	Ritonavir	—	298
9	Famotidine	—	296
10	Topotecan	—	300
11	Clonidine	—	299
12	Procainamide	—	297
13	Quinidine	—	298
14	ethopropazine	—	17
15	Phenformin	—	300
16	Carvedilol	—	296
17	Dextrorphan Dextro form of levorphanol. It acts as	—	300
18	Dinoprost	—	252
19	Dinoprostone	—	296
20	Guanabenz	—	298
21	Ipratropium	—	297
22	Levorphanol	—	297
23	Pindolol	—	299
24	Pramipexole	—	297
25	Buspirone	—	299
26	Dihydroergotamine	—	299
27	Domperidone	—	299
28	Gabexate	—	300
29	Sumatriptan	—	298
30	Tubocurarine	—	300
31	Vecuronium Bromide Monoquaternary homolog of PANCURONIUM.	—	298
32	N-Methylscopolamine	—	299
33	Colchicine	—	300
34	Desoxycorticosterone	—	300
35	thiamine	—	299
36	Aurintricarboxylic Acid	—	184
37	Dihydroxyphenylalanine	—	300
38	Disulfiram	—	297
39	Ethidium	—	300
40	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
41	Daunorubicin	—	298
42	Fusaric Acid	—	300
43	Harmaline	—	300
44	Acetylcarnitine	—	300
45	Ergothioneine	—	300

About the SLC-mediated transport of organic cations Pathway

The SLC-mediated transport of organic cations pathway is catalogued in Reactome (ID: R-HSA-549127) and involves 7 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include RUNX1, SLC22A1, SLC22A3, SLC22A4, SLC22A5.