What compounds affect the Physiological factors pathway?

24 compounds in the BiohacksAI corpus have documented interactions with genes in the Physiological factors pathway (Reactome ID: R-HSA-5578768). These compounds target 7 genes within this pathway.

What genes are in the Physiological factors pathway?

The Physiological factors pathway involves 7 genes. Key genes include: CES1, HIPK1, HIPK2, KAT2B, MME, NPR1, NPR2.

Physiological factors

REACTOME PATHWAY

Reactome: R-HSA-55787687 genes24 compounds

The Physiological factors pathway (Reactome ID: R-HSA-5578768) involves 7 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CES1 HIPK1 HIPK2 KAT2B MME NPR1 NPR2

Compounds Affecting Physiological factors

#	Compound	Targets Hit	Studies
1	Atrial Natriuretic Factor	—	300
2	Disulfiram	—	297
3	Niclosamide	—	299
4	Rotenone	—	300
5	tyrphostin 9	—	2
6	Sorafenib	—	300
7	pictilisib	—	25
8	Fluoxetine	—	1,000
9	Sertraline	—	1,000
10	Amoxapine	—	259
11	Cetirizine	—	296
12	Cyproheptadine	—	299
13	Loxapine	—	225
14	Noscapine	—	300
15	Perphenazine	—	297
16	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
17	sp600125	—	117
18	ly294002	—	11
19	np1	—	81
20	egcg	—	300
21	plumbagin [Supplementary Concept]	—	300
22	Ursolic Acid	—	300
23	Oleanolic Acid	—	300
24	Thiorphan	—	300

About the Physiological factors Pathway

The Physiological factors pathway is catalogued in Reactome (ID: R-HSA-5578768) and involves 7 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CES1, HIPK1, HIPK2, KAT2B, MME.