What compounds affect the Negative regulation of FGFR2 signaling pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Negative regulation of FGFR2 signaling pathway (Reactome ID: R-HSA-5654727). These compounds target 9 genes within this pathway.

What genes are in the Negative regulation of FGFR2 signaling pathway?

The Negative regulation of FGFR2 signaling pathway involves 9 genes. Key genes include: BRAF, FGF22, FGFR2, GRB2, MAPK1, MAPK3, MKNK1, PPP2CA, SRC.

Negative regulation of FGFR2 signaling

REACTOME PATHWAY

Reactome: R-HSA-56547279 genes37 compounds

The Negative regulation of FGFR2 signaling pathway (Reactome ID: R-HSA-5654727) involves 9 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF FGF22 FGFR2 GRB2 MAPK1 MAPK3 MKNK1 PPP2CA SRC

Compounds Affecting Negative regulation of FGFR2 signaling

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	tyrphostin ag 1478	—	4
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Dasatinib	—	299
6	plumbagin [Supplementary Concept]	—	300
7	pd98059	—	7
8	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
9	trametinib	—	296
10	withaferin	—	300
11	Quercetin	—	300
12	Afatinib	—	297
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Clotrimazole	—	296
15	sp600125	—	117
16	fisetin	—	78
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	Resveratrol	—	298
28	Adenosine Monophosphate Adenine nucleotide containing	—	300
29	Crizotinib	—	298
30	monorden	—	8
31	Niclosamide	—	299
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	hydroxyfasudil [Supplementary Concept]	—	11
34	Vemurafenib	—	298
35	Axitinib	—	298
36	Dactinomycin	—	297
37	Okadaic Acid	—	300

About the Negative regulation of FGFR2 signaling Pathway

The Negative regulation of FGFR2 signaling pathway is catalogued in Reactome (ID: R-HSA-5654727) and involves 9 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, FGF22, FGFR2, GRB2, MAPK1.