What compounds affect the Negative regulation of FGFR4 signaling pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Negative regulation of FGFR4 signaling pathway (Reactome ID: R-HSA-5654733). These compounds target 8 genes within this pathway.

What genes are in the Negative regulation of FGFR4 signaling pathway?

The Negative regulation of FGFR4 signaling pathway involves 8 genes. Key genes include: BRAF, FGFR4, GRB2, MAPK1, MAPK3, MKNK1, PPP2CA, SRC.

Negative regulation of FGFR4 signaling

REACTOME PATHWAY

Reactome: R-HSA-56547338 genes37 compounds

The Negative regulation of FGFR4 signaling pathway (Reactome ID: R-HSA-5654733) involves 8 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF FGFR4 GRB2 MAPK1 MAPK3 MKNK1 PPP2CA SRC

Compounds Affecting Negative regulation of FGFR4 signaling

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	tyrphostin ag 1478	—	4
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	plumbagin [Supplementary Concept]	—	300
6	pd98059	—	7
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	trametinib	—	296
9	withaferin	—	300
10	Dasatinib	—	299
11	Quercetin	—	300
12	Afatinib	—	297
13	Clotrimazole	—	296
14	sp600125	—	117
15	fisetin	—	78
16	Progesterone	—	299
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Benzalkonium Compounds	—	299
19	Calcimycin	—	216
20	daph	—	2
21	Diphenhydramine	—	14
22	ha1004	—	4
23	Lithocholic Acid	—	300
24	Loratadine	—	296
25	trequinsin hydrochloride	—	1
26	Resveratrol	—	298
27	Adenosine Monophosphate Adenine nucleotide containing	—	300
28	Crizotinib	—	298
29	monorden	—	8
30	Niclosamide	—	299
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
32	hydroxyfasudil [Supplementary Concept]	—	11
33	Vemurafenib	—	298
34	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
35	Acrylamide	—	300
36	Dactinomycin	—	297
37	Okadaic Acid	—	300

About the Negative regulation of FGFR4 signaling Pathway

The Negative regulation of FGFR4 signaling pathway is catalogued in Reactome (ID: R-HSA-5654733) and involves 8 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, FGFR4, GRB2, MAPK1, MAPK3.