What genes are in the Termination of translesion DNA synthesis pathway?

The Termination of translesion DNA synthesis pathway involves 5 genes. Key genes include: PCNA, POLH, POLI, POLK, USP10.

Termination of translesion DNA synthesis

Q: What compounds affect the Termination of translesion DNA synthesis pathway?

56 compounds in the BiohacksAI corpus have documented interactions with genes in the Termination of translesion DNA synthesis pathway (Reactome ID: R-HSA-5656169). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56561695 genes56 compounds

The Termination of translesion DNA synthesis pathway (Reactome ID: R-HSA-5656169) involves 5 genes and is affected by 56 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PCNA POLH POLI POLK USP10

Compounds Affecting Termination of translesion DNA synthesis

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	alpha-Linolenic Acid	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Ethidium	—	300
6	gamma-Linolenic Acid	—	300
7	Levodopa	—	297
8	Masoprocol	—	300
9	piceatannol	—	300
10	Cefixime	—	300
11	Diiodotyrosine	—	300
12	Idarubicin	—	299
13	Norepinephrine Precursor of epinephrine that is secreted by	—	298
14	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
15	Aurintricarboxylic Acid	—	184
16	Cefotetan	—	299
17	streptonigrin	—	299
18	Carmine Coloring matter from	—	300
19	candesartan cilexetil [Supplementary Concept]	—	300
20	Methyldopa	—	297
21	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
22	Catechin	—	300
23	Oxytetracycline	—	300
24	Kaempferols	—	300
25	Methotrexate	—	289
26	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
27	Epinephrine	—	299
28	Arachidonic Acid	—	245
29	fisetin	—	78
30	Daunorubicin	—	298
31	DEAD-box RNA Helicases	—	169
32	Thioctic Acid	—	298
33	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
34	Catechin	—	51
35	plumbagin [Supplementary Concept]	—	300
36	Resveratrol	—	298
37	Rutin	—	300
38	Anthralin	—	299
39	butein	—	158
40	Cimetidine	—	299
41	Demeclocycline	—	5
42	Dihydroxyphenylalanine	—	300
43	Estramustine	—	300
44	o-Phthalaldehyde	—	300
45	rafoxanide	—	172
46	Suramin	—	300
47	Thioctic Acid	—	300
48	Cisplatin	—	300
49	alphitonin [Supplementary Concept] from	—	300
50	Wortmannin	—	300

About the Termination of translesion DNA synthesis Pathway

The Termination of translesion DNA synthesis pathway is catalogued in Reactome (ID: R-HSA-5656169) and involves 5 genes. In the BiohacksAI corpus, 56 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PCNA, POLH, POLI, POLK, USP10.