Negative feedback regulation of MAPK pathway
REACTOME PATHWAYThe Negative feedback regulation of MAPK pathway pathway (Reactome ID: R-HSA-5674499) involves 6 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Negative feedback regulation of MAPK pathway
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | pd98059 | — | 7 |
| 3 | trametinib | — | 296 |
| 4 | Dasatinib | — | 299 |
| 5 | Vemurafenib | — | 298 |
| 6 | plumbagin [Supplementary Concept] | — | 300 |
| 7 | alsterpaullone | — | 12 |
| 8 | kenpaullone | — | 8 |
| 9 | isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from | — | 300 |
| 10 | withaferin | — | 300 |
| 11 | Axitinib | — | 298 |
| 12 | tyrphostin ag 1478 | — | 4 |
| 13 | Clotrimazole | — | 296 |
| 14 | sp600125 | — | 117 |
| 15 | fisetin | — | 78 |
| 16 | Progesterone | — | 299 |
| 17 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
| 18 | Benzalkonium Compounds | — | 299 |
| 19 | Calcimycin | — | 216 |
| 20 | daph | — | 2 |
| 21 | Diphenhydramine | — | 14 |
| 22 | ha1004 | — | 4 |
| 23 | Lithocholic Acid | — | 300 |
| 24 | Loratadine | — | 296 |
| 25 | trequinsin hydrochloride | — | 1 |
| 26 | arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from | — | 300 |
| 27 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 28 | Quercetin | — | 300 |
About the Negative feedback regulation of MAPK pathway Pathway
The Negative feedback regulation of MAPK pathway pathway is catalogued in Reactome (ID: R-HSA-5674499) and involves 6 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, MAP2K1, MAP2K2, MAPK1, MAPK3.