What compounds affect the Negative regulation of MAPK pathway pathway?

33 compounds in the BiohacksAI corpus have documented interactions with genes in the Negative regulation of MAPK pathway pathway (Reactome ID: R-HSA-5675221). These compounds target 15 genes within this pathway.

What genes are in the Negative regulation of MAPK pathway pathway?

The Negative regulation of MAPK pathway pathway involves 15 genes. Key genes include: ARAF, BRAF, DUSP5, MAP2K1, MAP2K2, MAPK1, MAPK12, MAPK3, MARK3, PPP2CA.

Negative regulation of MAPK pathway

REACTOME PATHWAY

Reactome: R-HSA-567522115 genes33 compounds

The Negative regulation of MAPK pathway pathway (Reactome ID: R-HSA-5675221) involves 15 genes and is affected by 33 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARAF BRAF DUSP5 MAP2K1 MAP2K2 MAPK1 MAPK12 MAPK3 MARK3 PPP2CA PPP2R5A PPP5C PTPN7 RAF1 YWHAB

Compounds Affecting Negative regulation of MAPK pathway

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Vemurafenib	—	298
3	pd98059	—	7
4	trametinib	—	296
5	Dasatinib	—	299
6	alsterpaullone	—	12
7	kenpaullone	—	8
8	sp600125	—	117
9	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
10	withaferin	—	300
11	plumbagin [Supplementary Concept]	—	300
12	Axitinib	—	298
13	Quercetin	—	300
14	Okadaic Acid	—	300
15	tyrphostin ag 1478	—	4
16	Clotrimazole	—	296
17	fisetin	—	78
18	Progesterone	—	299
19	2-Chloroadenosine 2-Chloroadenosine.	—	300
20	Benzalkonium Compounds	—	299
21	Calcimycin	—	216
22	daph	—	2
23	Diphenhydramine	—	14
24	ha1004	—	4
25	Lithocholic Acid	—	300
26	Loratadine	—	296
27	trequinsin hydrochloride	—	1
28	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	Anisomycin	—	247
31	ninhydrin	—	300
32	Suramin	—	300
33	Tetracycline	—	300

About the Negative regulation of MAPK pathway Pathway

The Negative regulation of MAPK pathway pathway is catalogued in Reactome (ID: R-HSA-5675221) and involves 15 genes. In the BiohacksAI corpus, 33 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARAF, BRAF, DUSP5, MAP2K1, MAP2K2.