What genes are in the HDR through Single Strand Annealing (SSA) pathway?

The HDR through Single Strand Annealing (SSA) pathway involves 10 genes. Key genes include: ABL1, ATM, BARD1, BLM, BRCA1, DNA2, RAD51, RAD52, RBBP8, WRN.

HDR through Single Strand Annealing (SSA)

Q: What compounds affect the HDR through Single Strand Annealing (SSA) pathway?

86 compounds in the BiohacksAI corpus have documented interactions with genes in the HDR through Single Strand Annealing (SSA) pathway (Reactome ID: R-HSA-5685938). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-568593810 genes86 compounds

The HDR through Single Strand Annealing (SSA) pathway (Reactome ID: R-HSA-5685938) involves 10 genes and is affected by 86 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ATM BARD1 BLM BRCA1 DNA2 RAD51 RAD52 RBBP8 WRN

Compounds Affecting HDR through Single Strand Annealing (SSA)

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	Nocodazole Nocodazole is	—	215
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Methylene Blue	—	200
5	Methotrexate	—	289
6	Astemizole Antihistamine drug now withdrawn from	—	280
7	Azacitidine	—	298
8	Azacitidine	—	300
9	Calcimycin	—	216
10	Ciclopirox	—	88
11	Colchicine	—	300
12	colchine	—	2
13	cycloheximide	—	300
14	Cytarabine	—	297
15	Demecolcine	—	246
16	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
17	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
18	dihydrorotenone	—	13
19	Fluspirilene	—	74
20	gedunin	—	54
21	Hexachlorophene	—	300
22	lidoflazine	—	278
23	Melphalan	—	300
24	Niclosamide	—	299
25	paxilline	—	42
26	Podophyllotoxin	—	14
27	rafoxanide	—	172
28	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
29	Trifluridine	—	295
30	Tubercidin	—	300
31	vinblastine sulfate	—	81
32	Imatinib Mesylate	—	300
33	Quercetin	—	300
34	Oxytetracycline	—	300
35	Aurintricarboxylic Acid	—	184
36	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
37	Levodopa	—	297
38	streptonigrin	—	299
39	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
40	Resveratrol	—	298
41	calycosin	—	300
42	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
43	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
44	Sorafenib	—	300
45	Axitinib	—	298
46	Dasatinib	—	299
47	Crizotinib	—	298
48	Afatinib	—	297
49	Avapritinib	—	246
50	Biotin	—	297

About the HDR through Single Strand Annealing (SSA) Pathway

The HDR through Single Strand Annealing (SSA) pathway is catalogued in Reactome (ID: R-HSA-5685938) and involves 10 genes. In the BiohacksAI corpus, 86 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ATM, BARD1, BLM, BRCA1.