What compounds affect the Metalloprotease DUBs pathway?

56 compounds in the BiohacksAI corpus have documented interactions with genes in the Metalloprotease DUBs pathway (Reactome ID: R-HSA-5689901). These compounds target 6 genes within this pathway.

What genes are in the Metalloprotease DUBs pathway?

The Metalloprotease DUBs pathway involves 6 genes. Key genes include: BARD1, BRCA1, EP300, KAT2B, NLRP3, PSMD14.

Metalloprotease DUBs

REACTOME PATHWAY

Reactome: R-HSA-56899016 genes56 compounds

The Metalloprotease DUBs pathway (Reactome ID: R-HSA-5689901) involves 6 genes and is affected by 56 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BARD1 BRCA1 EP300 KAT2B NLRP3 PSMD14

Compounds Affecting Metalloprotease DUBs

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	cycloheximide	—	300
3	Hexachlorophene	—	300
4	Niclosamide	—	299
5	Methotrexate	—	289
6	Astemizole Antihistamine drug now withdrawn from	—	280
7	Azacitidine	—	298
8	Azacitidine	—	300
9	Calcimycin	—	216
10	Ciclopirox	—	88
11	Colchicine	—	300
12	colchine	—	2
13	Cytarabine	—	297
14	Demecolcine	—	246
15	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
16	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
17	dihydrorotenone	—	13
18	Fluspirilene	—	74
19	gedunin	—	54
20	lidoflazine	—	278
21	Melphalan	—	300
22	Nocodazole Nocodazole is	—	215
23	paxilline	—	42
24	Podophyllotoxin	—	14
25	rafoxanide	—	172
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
27	Trifluridine	—	295
28	Tubercidin	—	300
29	vinblastine sulfate	—	81
30	Bortezomib	—	300
31	plumbagin [Supplementary Concept]	—	300
32	egcg	—	300
33	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
34	Resveratrol	—	298
35	calycosin	—	300
36	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
37	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
38	Androsterone	—	300
39	Dimethyl Fumarate	—	296
40	Etiocholanolone	—	300
41	Lithocholic Acid	—	300
42	tyrphostin 9	—	2
43	Calcitriol	—	300
44	Dihydrotestosterone	—	300
45	Ethinyl Estradiol	—	300
46	Thioridazine	—	35
47	20-alpha-Dihydroprogesterone	—	224
48	Anisomycin	—	247
49	oridonin	—	300
50	Tocainide	—	299

About the Metalloprotease DUBs Pathway

The Metalloprotease DUBs pathway is catalogued in Reactome (ID: R-HSA-5689901) and involves 6 genes. In the BiohacksAI corpus, 56 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BARD1, BRCA1, EP300, KAT2B, NLRP3.