What compounds affect the Nucleotide Excision Repair pathway?

77 compounds in the BiohacksAI corpus have documented interactions with genes in the Nucleotide Excision Repair pathway (Reactome ID: R-HSA-5696398). These compounds target 10 genes within this pathway.

What genes are in the Nucleotide Excision Repair pathway?

The Nucleotide Excision Repair pathway involves 10 genes. Key genes include: CDK7, COPS5, ERCC3, PARP1, PCNA, POLK, RBX1, SUMO1, UBE2N, USP7.

Nucleotide Excision Repair

REACTOME PATHWAY

Reactome: R-HSA-569639810 genes77 compounds

The Nucleotide Excision Repair pathway (Reactome ID: R-HSA-5696398) involves 10 genes and is affected by 77 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 COPS5 ERCC3 PARP1 PCNA POLK RBX1 SUMO1 UBE2N USP7

Compounds Affecting Nucleotide Excision Repair

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Quercetin	—	300
3	alpha-Linolenic Acid	—	300
4	Cefixime	—	300
5	Daunorubicin	—	298
6	DEAD-box RNA Helicases	—	169
7	Thioctic Acid	—	298
8	Resveratrol	—	298
9	Oxytetracycline	—	300
10	Thioctic Acid	—	300
11	Sphingosine	—	300
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Ethidium	—	300
14	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
15	Carmine Coloring matter from	—	300
16	Epinephrine	—	299
17	gamma-Linolenic Acid	—	300
18	Levodopa	—	297
19	Masoprocol	—	300
20	piceatannol	—	300
21	Arachidonic Acid	—	245
22	fisetin	—	78
23	candesartan cilexetil [Supplementary Concept]	—	300
24	Diiodotyrosine	—	300
25	Idarubicin	—	299
26	Methyldopa	—	297
27	Norepinephrine Precursor of epinephrine that is secreted by	—	298
28	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
29	Catechin	—	51
30	plumbagin [Supplementary Concept]	—	300
31	Rutin	—	300
32	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
33	Anthralin	—	299
34	Aurintricarboxylic Acid	—	184
35	butein	—	158
36	Cefotetan	—	299
37	Cimetidine	—	299
38	Demeclocycline	—	5
39	Dihydroxyphenylalanine	—	300
40	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
41	Catechin	—	300
42	Estramustine	—	300
43	o-Phthalaldehyde	—	300
44	rafoxanide	—	172
45	streptonigrin	—	299
46	Suramin	—	300
47	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
48	Bortezomib	—	300
49	Camptothecin	—	300
50	Clofarabine	—	298

About the Nucleotide Excision Repair Pathway

The Nucleotide Excision Repair pathway is catalogued in Reactome (ID: R-HSA-5696398) and involves 10 genes. In the BiohacksAI corpus, 77 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, COPS5, ERCC3, PARP1, PCNA.